CAJ | 학술논문

目的研究持续植物状态（ PVS）患者磁共振波谱分析（ MRS）影像学特征，分析MRS对PVS预后判断能力。方法对病例组（ PVS患者28例）治疗前行MRS检查，测定丘脑、基底节NAA/Cr、Cho/Cr、NAA/Cho的比值，与对照组（健康体检者30例）对比差异，对所测结果与临床综合治疗后PVS总疗效评分进行统计学分析。结果丘脑、基底节可视损伤区MRS表现与对照组间存在显著性差异（ P＜0.01），表观正常区MRS表现与对照组也存在统计学差异（ P＜0.05），且该差异性导致丘脑NAA/Cr、NAA/Cho比值以及基底节NAA/Cr比值与PVS总疗效评分分级之间呈正相关。结论 MRS在PVS预后中的作用具有非常好的价值和潜力，丘脑表观正常区及NAA/Cr比值可作为较好的感兴趣区及判断指标。
목적연구지속식물상태（ PVS）환자자공진파보분석（ MRS）영상학특정，분석MRS대PVS예후판단능력。방법대병례조（ PVS환자28례）치료전행MRS검사，측정구뇌、기저절NAA/Cr、Cho/Cr、NAA/Cho적비치，여대조조（건강체검자30례）대비차이，대소측결과여림상종합치료후PVS총료효평분진행통계학분석。결과구뇌、기저절가시손상구MRS표현여대조조간존재현저성차이（ P＜0.01），표관정상구MRS표현여대조조야존재통계학차이（ P＜0.05），차해차이성도치구뇌NAA/Cr、NAA/Cho비치이급기저절NAA/Cr비치여PVS총료효평분분급지간정정상관。결론 MRS재PVS예후중적작용구유비상호적개치화잠력，구뇌표관정상구급NAA/Cr비치가작위교호적감흥취구급판단지표。
Objective To explore whether proton magnetic resonance spectroscopy ( MRS ) , a newer radiographic technology ,would be useful in the evaluation of the patients in persistent vegetative state .Methods 28 patients who were in the vegetative state before being treatment and 30 healthy volunteer both had proton MRS studies.NAA/Cr and Cho/Cr and NAA/Cho ratios were obtained for each patient in the dorsal thalamus and basal ganglia,and then statistical analysis was performed .Results There was significant difference between PVS group and the control group of MRS in Thalamus,basal ganglia visible damage zone(P<0.05).Also there was the same result in apparent normal zone ( P<0.05 ) .Differences in NAA/Cr, NAA/Cho ratio of hypothalamic and NAA/Cr ratio of basal ganglia were positively correlated with PVS efficacy score grading .Conclusion For attempting to predict PVS prognosis , MRS has a very good value and potential .The apparent normal zone of hypothalamus and NAA/Cr ratio may be a good choice of VOI and evaluation index .