中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
11期
4717-4721
,共5页
胥阳%王丽宁%李晗%王觉%蔡辉
胥暘%王麗寧%李晗%王覺%蔡輝
서양%왕려저%리함%왕각%채휘
乳腺肿瘤%Raf-1%Ki67%新辅助化疗
乳腺腫瘤%Raf-1%Ki67%新輔助化療
유선종류%Raf-1%Ki67%신보조화료
Breast neoplasms%Raf-1%Ki67%Neoadjuvant chemotherapy
目的探讨Raf-1和Ki67在乳腺癌表达水平与临床病理特征相关性，并研究其在新辅助化疗前后的变化。方法采用免疫组织化学方法（ SP法）检测186例乳腺癌病理组织中的Raf-1和Ki67的阳性表达情况，其中包括68例新辅助化疗前后的组织标本。结果乳腺癌组织中Raf-1和Ki67的表达与淋巴结有无转移和病理分期、临床分期等有关（ P＜0.001）；新辅助化疗后Raf-1和Ki67的阳性表达较新辅助化疗前均有所下降，差异有统计学意义（ P＜0.001）；Raf-1和Ki67在新辅助化疗前后的表达变化值与化疗疗效明显相关（ P＜0.001），新辅助化疗效果越好，Raf-1蛋白和Ki67下降越明显。结论 Raf-1和Ki67阳性表达与乳腺癌的发生发展具有密切的相关性。新辅助化疗影响Raf-1和Ki67的表达，新辅助化疗后应重新检测Raf-1和Ki67的表达，为后续治疗及判断预后提供指导。
目的探討Raf-1和Ki67在乳腺癌錶達水平與臨床病理特徵相關性，併研究其在新輔助化療前後的變化。方法採用免疫組織化學方法（ SP法）檢測186例乳腺癌病理組織中的Raf-1和Ki67的暘性錶達情況，其中包括68例新輔助化療前後的組織標本。結果乳腺癌組織中Raf-1和Ki67的錶達與淋巴結有無轉移和病理分期、臨床分期等有關（ P＜0.001）；新輔助化療後Raf-1和Ki67的暘性錶達較新輔助化療前均有所下降，差異有統計學意義（ P＜0.001）；Raf-1和Ki67在新輔助化療前後的錶達變化值與化療療效明顯相關（ P＜0.001），新輔助化療效果越好，Raf-1蛋白和Ki67下降越明顯。結論 Raf-1和Ki67暘性錶達與乳腺癌的髮生髮展具有密切的相關性。新輔助化療影響Raf-1和Ki67的錶達，新輔助化療後應重新檢測Raf-1和Ki67的錶達，為後續治療及判斷預後提供指導。
목적탐토Raf-1화Ki67재유선암표체수평여림상병리특정상관성，병연구기재신보조화료전후적변화。방법채용면역조직화학방법（ SP법）검측186례유선암병리조직중적Raf-1화Ki67적양성표체정황，기중포괄68례신보조화료전후적조직표본。결과유선암조직중Raf-1화Ki67적표체여림파결유무전이화병리분기、림상분기등유관（ P＜0.001）；신보조화료후Raf-1화Ki67적양성표체교신보조화료전균유소하강，차이유통계학의의（ P＜0.001）；Raf-1화Ki67재신보조화료전후적표체변화치여화료료효명현상관（ P＜0.001），신보조화료효과월호，Raf-1단백화Ki67하강월명현。결론 Raf-1화Ki67양성표체여유선암적발생발전구유밀절적상관성。신보조화료영향Raf-1화Ki67적표체，신보조화료후응중신검측Raf-1화Ki67적표체，위후속치료급판단예후제공지도。
Objective To investigate the expression of Raf-1 and Ki67 in breast cancer correlation levels with clinical pathological characteristics , and study on their changes before and after neoadjuvant chemotherapy . Methods Using immunohistochemical method ( SP method ) to detect the positive expression of Raf-1 and Ki67 in breast cancer tissue of 186 cases,including tissue samples of 68 cases before and after neoadjuvant chemotherapy . Results The expressions of Raf-1 and Ki67 in breast cancer were significantly correlated with clinical stages and lymph node metastasis and TNM stage ( P<0.001 );After neoadjuvant chemotherapy in the positive expressions of Raf-1 and Ki67 than before neoadjuvant chemotherapy were decreased ,the difference was statistically significant ( P<0.001 );Raf-1 and Ki67 changes in the expression of the value before and after neoadjuvant chemotherapy were significantly associated with chemotherapy ( P <0.001 ) , the better the effect of neoadjuvant chemotherapy , Raf-1 protein and Ki67 decreased more obviously .Conclusions There was close relationship between the occurrence and development and positive expression of Raf-1 and Ki67 in breast cancer .Effects of neoadjuvant chemotherapy on expression of Raf-1 and Ki67, after neoadjuvant chemotherapy to detect expression of Raf-1 and Ki67, provide guidance for the follow-up treatment and prognosis .
