CAJ | 학술논문

目的探讨结直肠腺癌中出现神经内分泌细胞分化的临床病理学意义。方法对147例结直肠癌的临床病理资料进行分析，免疫组化检测神经内分泌标记物嗜铬素（ CgA）、突触素（ Syn）在肿瘤组织中的表达。比较伴与不伴神经内分泌细胞分化的两组结直肠癌患者的临床病理特征差异。结果147例结直肠腺癌，伴神经内分泌细胞分化22例（15.0％）。其中CgA阳性15例，Syn阳性12例，CgA与Syn同时阳性为5例。其肿瘤组织学分级、淋巴结转移率、脉管瘤栓检出率均高于不伴神经内分泌细胞分化的结直肠癌（ P均＜0.05）。结论结直肠癌伴神经内分泌细胞分化患者较不伴神经内分泌细胞分化的患者组织学分化更低，且更易发生淋巴结及脉管转移，预后较差。结直肠癌伴神经内分泌细胞分化可能是预后不良的重要因素之一。
목적탐토결직장선암중출현신경내분비세포분화적림상병이학의의。방법대147례결직장암적림상병리자료진행분석，면역조화검측신경내분비표기물기락소（ CgA）、돌촉소（ Syn）재종류조직중적표체。비교반여불반신경내분비세포분화적량조결직장암환자적림상병리특정차이。결과147례결직장선암，반신경내분비세포분화22례（15.0％）。기중CgA양성15례，Syn양성12례，CgA여Syn동시양성위5례。기종류조직학분급、림파결전이솔、맥관류전검출솔균고우불반신경내분비세포분화적결직장암（ P균＜0.05）。결론결직장암반신경내분비세포분화환자교불반신경내분비세포분화적환자조직학분화경저，차경역발생림파결급맥관전이，예후교차。결직장암반신경내분비세포분화가능시예후불량적중요인소지일。
Objective To investigate the clinicopathological characteristics of colorectal carcinoma with neuroendocrine cell differentiation ( NED ) .Methods One hundred and forty-seven cases of colorectal carcinoma were retrospectively analyzed .Expression of neuroendocrine markers , CgA and Syn, was detected by immunohistochemistry .Various clinical and pathological data of the patients were compared between carcinomas with and without NED components .Results Of the 147 colorectal cancer patients , 22 ( 15.0%) were diagnosed as carcinoma with NED.15 cases were CgA positive,12 cases were Syn positive.Syn and CgA were positive in 5 cases. Tumor histological differentiation ,lymph metastasis and vessel invasion were significantly related with NED ( all P<0.05 ) .Conclusion The prognosis is poorer in colorectal cancer patients with NED than those without NED after operation .Colorectal carcinoma with NED may be one of the most important factors for the poor prognosis of patients .