CAJ | 학술논문

目的评价肝动脉化疗栓塞治疗原发性肝癌伴门静脉癌栓的疗效。方法回顾性分析2006年1月至2010年9月收治的125例原发性肝癌伴门静脉癌栓行TACE治疗的患者资料并做生存分析。结果125例患者的中位生存时间为（7.0±0.96）个月，1、2年的生存率分别为29.6％、18.5％。肿瘤和癌栓的有效率分别为56.0％和42.4％。单因素分析显示ECOG评分、甲胎蛋白含量、肿瘤直径、TACE次数是影响患者的预后因素。多因素分析显示肿瘤直径和TACE次数是影响患者预后的主要因素。结论肝动脉化疗栓塞治疗原发性肝癌伴不同程度的门静脉癌栓均有效，肿瘤直径＜100 mm和TACE次数≥3次的患者预后较好。
목적평개간동맥화료전새치료원발성간암반문정맥암전적료효。방법회고성분석2006년1월지2010년9월수치적125례원발성간암반문정맥암전행TACE치료적환자자료병주생존분석。결과125례환자적중위생존시간위（7.0±0.96）개월，1、2년적생존솔분별위29.6％、18.5％。종류화암전적유효솔분별위56.0％화42.4％。단인소분석현시ECOG평분、갑태단백함량、종류직경、TACE차수시영향환자적예후인소。다인소분석현시종류직경화TACE차수시영향환자예후적주요인소。결론간동맥화료전새치료원발성간암반불동정도적문정맥암전균유효，종류직경＜100 mm화TACE차수≥3차적환자예후교호。
Objective To assess the therapeutic effectiveness of transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombosis .Methods Retrospectively studied 125 HCC with PVTT patients and stratified the PVTT .The effectiveness and prognostic factors were evaluated .Results The median survival time was ( 7.0 ±0.96 ) months, the 1-and 2-year survival rate was 29.6%, 18.5%, respectively.The effective rate of tumor and PVTT were 56.0%,42.4%,respectively.Univariate analysis showed the ECOG,AFP, tumor size and times of TACE were significant prognostic factors for overall survival .Multivariate analysis showed the tumor size,times of TACE were significant prognostic factors for overall survival .Conclusion TACE is effective and safe for HCC patients with different types of PVTT .Patients with tumor diameter less than 100 mm,treated with TACE more than two times ,have good prognosis .