CAJ | 학술논문

[目的]观察牡蛎、石决明、瓦楞子、珍珠母、紫贝齿、蛤壳6种介类中药对大鼠甲状腺肿大的影响。[方法]72只健康SD大鼠随机分为9组：正常组、模型组、阳性组及6个介类中药组。每日灌胃丙硫氧嘧啶（0.15g·kg-1），连续造模10d，称量甲状腺湿重，酶联免疫法测血清T3、T4、TSH含量，观察光镜下甲状腺的形态变化。[结果]模型组大鼠较正常组甲状腺相对重量增加，T3、T4含量降低，且均有显著性差异（P<0.01），甲状腺滤泡上皮细胞增生明显；与模型组比较，牡蛎、蛤壳组使大鼠T3、T4含量均回升，且均有显著性差异（P<0.05）；牡蛎、蛤壳组甲状腺滤泡上皮细胞增生不明显，其他4种介类中药组均有不同程度的增生。[结论]牡蛎、蛤壳对甲状腺肿模型大鼠甲状腺功能均有较好的改善作用。
[목적]관찰모려、석결명、와릉자、진주모、자패치、합각6충개류중약대대서갑상선종대적영향。[방법]72지건강SD대서수궤분위9조：정상조、모형조、양성조급6개개류중약조。매일관위병류양밀정（0.15g·kg-1），련속조모10d，칭량갑상선습중，매련면역법측혈청T3、T4、TSH함량，관찰광경하갑상선적형태변화。[결과]모형조대서교정상조갑상선상대중량증가，T3、T4함량강저，차균유현저성차이（P<0.01），갑상선려포상피세포증생명현；여모형조비교，모려、합각조사대서T3、T4함량균회승，차균유현저성차이（P<0.05）；모려、합각조갑상선려포상피세포증생불명현，기타4충개류중약조균유불동정도적증생。[결론]모려、합각대갑상선종모형대서갑상선공능균유교호적개선작용。
[Objective] To observe the effects of Oysters, Abalone shel , Concha arcae, Mother-of-pearl, Concha cypraeae, Clamshel , these six testacean TCM on the goiter rats. [Method] 72 healthy SD rats were randomly divided into nine groups:normal group, model group, positive group and six testacean TCM groups. Rats were given daily propylthiouracil (0.15 g·kg-1), continuous modeling for 10d, weighing thyroid wet weight,assaying T3, T4 and TSH contents in serum by ELISA, observing the morphological changes of thyroid under light microscope. [Result] Rats in the model group compared with normal group in-creased the relative weight of thyroid, reduced the content of T3,T4, and there was a significant difference( P<0.01), thyroid fol icular epithelial cellhyperplasia was obvious;compared with the model group, Oysters and Clamshel group made the content of T3,T4 in rat rebound, and there was a significant difference (P<0.05);Oyster and Clamshel group’s thyroid fol icular cellhyperplasia were not obvious, while the hyperplasia had different levels for the other 4 kinds of testacean TCM. [Conclusion] Oysters and Clamshel were better to improve the thyroid function of the goiter model rats.