CAJ | 학술논문

[目的]观察由芳香开窍药组成的嗅吸剂应用在急性颅脑创伤（traumatic brain injury,TBI）治疗中的脑组织血供情况变化及预后。[方法]选取我院TBI患者40例，按入院先后随机分为治疗组和对照组各20例,全部患者入院后均给予常规治疗，治疗组入院第2d起另给予芳香开窍嗅吸剂雾化嗅吸。两组分别于入院后第2d、第4d、第6d、第8d、第11d行颅多普勒（transcranial doppler sonography, TCD）检查脑血流变化以及神经系统检查和格拉斯哥昏迷计分法（GCS）评分。[结果]给予芳香开窍嗅吸剂治疗后，治疗组GCS评分在第6、8、11d明显高于对照组，差异有统计学意义（P<0.05和P<0.01），治疗组Vs、Vm、PI值与对照组相比明显改善，具有统计学差异(P<0.01和P<0.001)。[结论]芳香开窍药组成的嗅吸剂可以改善TBI患者的脑组织血供情况及预后，其机制可能是与芳香开窍药对脑缺血、缺氧有保护作用。
[목적]관찰유방향개규약조성적후흡제응용재급성로뇌창상（traumatic brain injury,TBI）치료중적뇌조직혈공정황변화급예후。[방법]선취아원TBI환자40례，안입원선후수궤분위치료조화대조조각20례,전부환자입원후균급여상규치료，치료조입원제2d기령급여방향개규후흡제무화후흡。량조분별우입원후제2d、제4d、제6d、제8d、제11d행로다보륵（transcranial doppler sonography, TCD）검사뇌혈류변화이급신경계통검사화격랍사가혼미계분법（GCS）평분。[결과]급여방향개규후흡제치료후，치료조GCS평분재제6、8、11d명현고우대조조，차이유통계학의의（P<0.05화P<0.01），치료조Vs、Vm、PI치여대조조상비명현개선，구유통계학차이(P<0.01화P<0.001)。[결론]방향개규약조성적후흡제가이개선TBI환자적뇌조직혈공정황급예후，기궤제가능시여방향개규약대뇌결혈、결양유보호작용。
[Objective] Observation aromatic resuscitation drug composed of olfactory sucking agent application in the treatment of acute traumatic cerebral tis-sue blood supply changes and prognosis. [Methods] Craniocerebral trauma patients 40 cases admitted are randomly divided into treatment group and against group with 20 cases, al patients are given general treatment, treatment group from 2nd day given aromatic resuscitation drug olfactory sucking agent powder by atomization, two groups respectively at 2nd day, 4th day, 6th day, 8th day, and 11th day, by TCD check of brain blood flow changes and nervous system and GCS scoring. [Results] Two sets of cerebral blood flow in patients with Vs, Vm, 2 d PI values are not significantly different, aromatic resuscitation after sniffing in the treatment, the treatment group Vs, Vm, PI value compared with the control group improves significantly. [Conclusion] Aromatic resuscitation drug composed of olfactory sucking agent can improve head trauma patients of brain organization blood for situation and the prognosis, its mechanism may be aromatic resuscitation drug effect on brain deficiency blood, and hypoxia has protection role;put drug of micro-powder with nasal olfactory sucking through nasal mucosa-cerebrospinal fluid way into brain, breakthrough or bypass blood brain barrier, improving head trauma patients of brain organization blood.