CAJ | 학술논문

目的：采用荟萃分析方法对华法林预防维持性血透患者导管功能不良的疗效和安全性进行评价。方法通过计算机检索中国生物医学文献数据库（CBM）、CNKI全文数据库、万方数据知识服务平台、维普全文数据库和PubMed数据库，并检索相应文献的参考文献。对符合纳入标准的文献以 Jadad评分标准进行评分，采用Revman 5.0对华法林预防维持性血透患者导管功能不良的疗效和不良反应进行荟萃分析。结果经筛选后共纳入3篇随机对照试验，病例总数403例，试验组和对照组分别为209例和194例。口服华法林组出现导管功能不良事件的发生率的差异无统计学意义（OR=0.51，95%，CI：0.13～1.99，P=0.33）。结论口服华法林不能改善维持性血透患者导管功能不良的发生率。
목적：채용회췌분석방법대화법림예방유지성혈투환자도관공능불량적료효화안전성진행평개。방법통과계산궤검색중국생물의학문헌수거고（CBM）、CNKI전문수거고、만방수거지식복무평태、유보전문수거고화PubMed수거고，병검색상응문헌적삼고문헌。대부합납입표준적문헌이 Jadad평분표준진행평분，채용Revman 5.0대화법림예방유지성혈투환자도관공능불량적료효화불량반응진행회췌분석。결과경사선후공납입3편수궤대조시험，병례총수403례，시험조화대조조분별위209례화194례。구복화법림조출현도관공능불량사건적발생솔적차이무통계학의의（OR=0.51，95%，CI：0.13～1.99，P=0.33）。결론구복화법림불능개선유지성혈투환자도관공능불량적발생솔。
Objective To evaluate the ef ectiveness and safety of warfarin in the prevention of catheter dysfunction in hemodialysis patients by meta analysis. Methods Searched from CBM,CNKI,Wanfang database,VIP and PubMed database,retrieved the corresponding literature references. The references meeting inclusive criteria were scored by Jadad grading standard,the ef icacy and adverse reactions of warfarin to prevent catheter dysfunction in hemodialysis patients were Meta-analysised through Revman 5.0. Results Total y 3 randomized control ed clinical trials were analyzed by screening,including 403 patients with 209 cases in treatment group and 194 in the control group.It showed no significant dif erences (OR=0.51,95%CI:0.13~1.99, P=0.33) in the incidences of catheter dysfunction in oral warfarin group and the control ed group. Conclusion Oral warfarin could not improve the incidence of catheter dysfunction in patients with maintenance hemodialysis.