医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
22期
62-62
,共1页
王聪敏%孟新科%黎小群%陈晖%李丹卉%谭微
王聰敏%孟新科%黎小群%陳暉%李丹卉%譚微
왕총민%맹신과%려소군%진휘%리단훼%담미
脂肪乳%血液净化%氯氮平%TISS-28
脂肪乳%血液淨化%氯氮平%TISS-28
지방유%혈액정화%록담평%TISS-28
Lipid infusion%Hemopurification%Clozapine%Poisoning%TISS-28
目的：探讨脂肪乳治疗氯氮平中毒治疗干预措施的临床效价比。方法回顾性分析17例氯氮平中毒病例资料，比较血液净化治疗组（10例）与脂肪乳治疗组（7例）血药浓度清除率，住院时间、医疗花费、住院期间日均治疗干预评分（TISS-28）之间的差异。结果脂肪乳治疗的氯氮平清除率（31.8%～34.3%/次）与血浆置换（29.2%～31.6%/次）接近，显著高于血液透析（12.7%～16.6%）和血液灌流（19.9%～21.4%）。脂肪乳组患者住院时间明显短于血液净化组（11.7±8.3d VS 19.9±18.4d,P=0.004），医疗花费（26813.45±17462.88元VS 7498.33±4166.51元,P=0.000）及日均TISS-28评分（41.2±20.3分VS 28.1±11.4分，P=0.008）均低于于血液净化组，差异均有统计学意义（P<0.01）。结论脂肪乳对氯氮平中毒的疗效与血浆置换相近，优于血液灌流或透析；可显著减少治疗干预措施，临床效价比较好，值得进一步深入研究。
目的：探討脂肪乳治療氯氮平中毒治療榦預措施的臨床效價比。方法迴顧性分析17例氯氮平中毒病例資料，比較血液淨化治療組（10例）與脂肪乳治療組（7例）血藥濃度清除率，住院時間、醫療花費、住院期間日均治療榦預評分（TISS-28）之間的差異。結果脂肪乳治療的氯氮平清除率（31.8%～34.3%/次）與血漿置換（29.2%～31.6%/次）接近，顯著高于血液透析（12.7%～16.6%）和血液灌流（19.9%～21.4%）。脂肪乳組患者住院時間明顯短于血液淨化組（11.7±8.3d VS 19.9±18.4d,P=0.004），醫療花費（26813.45±17462.88元VS 7498.33±4166.51元,P=0.000）及日均TISS-28評分（41.2±20.3分VS 28.1±11.4分，P=0.008）均低于于血液淨化組，差異均有統計學意義（P<0.01）。結論脂肪乳對氯氮平中毒的療效與血漿置換相近，優于血液灌流或透析；可顯著減少治療榦預措施，臨床效價比較好，值得進一步深入研究。
목적：탐토지방유치료록담평중독치료간예조시적림상효개비。방법회고성분석17례록담평중독병례자료，비교혈액정화치료조（10례）여지방유치료조（7례）혈약농도청제솔，주원시간、의료화비、주원기간일균치료간예평분（TISS-28）지간적차이。결과지방유치료적록담평청제솔（31.8%～34.3%/차）여혈장치환（29.2%～31.6%/차）접근，현저고우혈액투석（12.7%～16.6%）화혈액관류（19.9%～21.4%）。지방유조환자주원시간명현단우혈액정화조（11.7±8.3d VS 19.9±18.4d,P=0.004），의료화비（26813.45±17462.88원VS 7498.33±4166.51원,P=0.000）급일균TISS-28평분（41.2±20.3분VS 28.1±11.4분，P=0.008）균저우우혈액정화조，차이균유통계학의의（P<0.01）。결론지방유대록담평중독적료효여혈장치환상근，우우혈액관류혹투석；가현저감소치료간예조시，림상효개비교호，치득진일보심입연구。
Objective:To explore the clinicpotency ratioof treating intervention on clozapine poisoning treated with lipid infusion. Methods:Data of 17 patients with clozapine poisoning were analyzedretrospectively. Theblood concentrationof clozapine,long of stay,medical costand average TISS -28 per day were compared betweenhemopurificationgroup (10 cases)and lipid infusion group (7cases)respectively. Results:The clearance rate ofblood concentrationof clozapine in lipid infusion treatment group(31.8%~34.3%per one time)was closed to that ofplasmapheresisgroup(29.2%~31.6%per one time);exceeded to that of inhemoperfusion(19.9%~21.4%per one time)and hemodialysis (12.7%~16.6%per one time)significantly. The long of stay in lipid infusion treatment group (11.7 ±8.3d)was significantly shorter than that of inhemopurificationgroup(19.9±18.4d),P=0.004;but al ofmedical cost(26813.45±17462.88yuanVS 7498.33±4166.51yuan, P=0.000)and TISS-28(41.2±20.3VS 28.1±11.4,P=0.008)were inferior to that of inhemopurificationgroup. Conclusion:Thecurative ef ectof clozapine poisoning treated with lipid infusion isclose tothat ofplasmapheresis,and superior to that ofhemoperfusionand hemodialysis.The treatment of lipid infusion maybe can decrease the treating interventions and has bet er clinic potency ratio than that ofhemopurification.
