世界最新医学信息文摘（电子版）
世界最新醫學信息文摘（電子版）
세계최신의학신식문적（전자판）
World Latest Medicine Information
2013年
22期
27-28
,共2页
注射用兰索拉吐%含量测定%有关物质%高效液相色谱法
註射用蘭索拉吐%含量測定%有關物質%高效液相色譜法
주사용란색랍토%함량측정%유관물질%고효액상색보법
lansoprazole for injection%determination%related substance%HPLC
目的采用高效液相色谱法建立注射用兰索拉唾中兰索拉唾有关物质检查及其含量测定方法。方法AgilentZORBAXSB-C18柱(4.6X250mm,5μm),以甲醇：水：三乙胺：鱗酸(700：300：5：1.5, pH为7.3)为流动相，检测波长为284nm。结果在选定的色谱条件下，主峰和紧邻杂质峰能得到更好的分离.结论本方法简便、快速、准确，灵敏度高、专属性好，适用于注射用兰索拉唾含量及有关物质测定。
目的採用高效液相色譜法建立註射用蘭索拉唾中蘭索拉唾有關物質檢查及其含量測定方法。方法AgilentZORBAXSB-C18柱(4.6X250mm,5μm),以甲醇：水：三乙胺：鱗痠(700：300：5：1.5, pH為7.3)為流動相，檢測波長為284nm。結果在選定的色譜條件下，主峰和緊鄰雜質峰能得到更好的分離.結論本方法簡便、快速、準確，靈敏度高、專屬性好，適用于註射用蘭索拉唾含量及有關物質測定。
목적채용고효액상색보법건립주사용란색랍타중란색랍타유관물질검사급기함량측정방법。방법AgilentZORBAXSB-C18주(4.6X250mm,5μm),이갑순：수：삼을알：린산(700：300：5：1.5, pH위7.3)위류동상，검측파장위284nm。결과재선정적색보조건하，주봉화긴린잡질봉능득도경호적분리.결론본방법간편、쾌속、준학，령민도고、전속성호，괄용우주사용란색랍타함량급유관물질측정。
Objective To establish a HPLC method for determmg the content of Lansoprazole for Injection and screening its related substance in lansoprazole for mjection.Methods A Agilent ZORBAX SB-C18 column (4.6 mmx250 mm, 5μm) was used. The mobile phase was methanol:water:triethylamme:phosphonc acid (700:300:5:1.5,pH 7.3). The determination wave length was 284 nm.Results Under this selected chromatograph condition, the prominent peak and the neighbor subsidiary peak could be better separated. Conclusion The method is simple,speedy, accurate, accurate sensitive, specific and suitable for the content and related substances determination of Lansoprazole for Injection.
