CAJ | 학술논문

目的：探讨阿托伐他汀的药理作用及临床应用。方法2011年7月至2013年6月我院共收治52例家族性高胆固醇血症（FH）患者，治疗方案为口服阿托伐他汀，分别于治疗前后检测高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、三酰甘油（TG）、总胆固醇（TC）、C反应蛋白（CRP）指标并进行比较。结果治疗后患者的HDL-C均比治疗前升高，而LDL-C、TC、TG以及CRP均比治疗降低，差异明显，有统计学意义(P<0.05)。治疗期间，有3例患者出现便秘、腹胀、消化不良等可耐受的不良反应，所有患者均未出现的严重不良反应。结论应用阿托伐他汀治疗FH，临床效果显著，而且不良反应发生率低，安全可靠，可在临床应用。
목적：탐토아탁벌타정적약리작용급림상응용。방법2011년7월지2013년6월아원공수치52례가족성고담고순혈증（FH）환자，치료방안위구복아탁벌타정，분별우치료전후검측고밀도지단백（HDL-C）、저밀도지단백（LDL-C）、삼선감유（TG）、총담고순（TC）、C반응단백（CRP）지표병진행비교。결과치료후환자적HDL-C균비치료전승고，이LDL-C、TC、TG이급CRP균비치료강저，차이명현，유통계학의의(P<0.05)。치료기간，유3례환자출현편비、복창、소화불량등가내수적불량반응，소유환자균미출현적엄중불량반응。결론응용아탁벌타정치료FH，림상효과현저，이차불량반응발생솔저，안전가고，가재림상응용。
Objective To explore the pharmacological action and clinical application of atorvastatin. Methods The hospital treated 52 cases of familial hypercholesterolemia patients were given oral atorvastatin treatment, compared before and after treatment of high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), triglyceride (TG three), total cholesterol (TC), C reactive protein (CRP) and other indicators.Results After treatment than before treatment in patients with HDL-C increased, while LDL-C, TC, TG and CRP were decreased signiifcantly, the treatment, there was statistically signiifcant (P<0.05). Treatment of patients with only 3 patients had mild appetite decrease adverse reactions (without treatment improved), all the patients had no serious adverse events occurred. Conclusion Atorvastatin has good clinical efifcacy in treatment of familial hypercholesterolemia, good safety, no serious adverse reactions, it is worthy of clinical use.