CAJ | 학술논문

目的探讨BAG-1与脑膜瘤瘤周水肿及术后复发的关系。方法取158例脑膜瘤病理标本，采用免疫组化SP法直接检测BAG-1的表达情况。按染色强度和阳性范围评估免疫组化检测结果，分析BAG-1表达水平[以免疫组化评分（IHS）表示]与脑膜瘤瘤周水肿及术后复发的关系。结果 WHOⅠ级（上皮、纤维、混合、微囊、砂粒型）、Ⅱ级（不典型和脊索样型）、Ⅲ级（乳头型和间变型）的各亚型脑膜瘤BAG-1表达水平的差异有统计学意义（P＜0.05或0.01）。术后复发患者24例，呈高表达状态3例（12.50%）；未复发患者134例，呈高表达状态102例（76.12%）。术后复发者IHS增高者明显少于未复发者，差异有统计学意义（P＜0.05）。瘤周水肿程度为0级与1级、2级与3级的患者其IHS高低例数分布的差异均无统计学意义（均P＞0.05）；但在0、1级与2、3级的两两比较中，差异均有统计学意义（均P＜0.05）。结论脑膜瘤瘤周水肿及术后复发均与细胞凋亡有关，脑膜瘤BAG-1表达水平越低，其瘤周水肿越重，术后更易复发。
목적탐토BAG-1여뇌막류류주수종급술후복발적관계。방법취158례뇌막류병리표본，채용면역조화SP법직접검측BAG-1적표체정황。안염색강도화양성범위평고면역조화검측결과，분석BAG-1표체수평[이면역조화평분（IHS）표시]여뇌막류류주수종급술후복발적관계。결과 WHOⅠ급（상피、섬유、혼합、미낭、사립형）、Ⅱ급（불전형화척색양형）、Ⅲ급（유두형화간변형）적각아형뇌막류BAG-1표체수평적차이유통계학의의（P＜0.05혹0.01）。술후복발환자24례，정고표체상태3례（12.50%）；미복발환자134례，정고표체상태102례（76.12%）。술후복발자IHS증고자명현소우미복발자，차이유통계학의의（P＜0.05）。류주수종정도위0급여1급、2급여3급적환자기IHS고저례수분포적차이균무통계학의의（균P＞0.05）；단재0、1급여2、3급적량량비교중，차이균유통계학의의（균P＜0.05）。결론뇌막류류주수종급술후복발균여세포조망유관，뇌막류BAG-1표체수평월저，기류주수종월중，술후경역복발。
Objective To investigate the relationship between BAG- 1 expression with postoperative recurrent and peritu-moral edema in patients with meningioma. Methods The expression of BAG- 1 was detected with immunohistochemical SP method in brain tissue specimens from 158 patients with meningioma. The relationship of BAG- 1 expression in meningioma with peritumoral edema and postoperative recurrence was analyzed. Results There was significant difference in BAG- 1 expression degree between grade I meningioma(including epithelial, fibril ar, mixed, microcystic and psammomatous subtypes) and grade II (atypical, chordoid subtypes) or grade III (papil ary, anaplastic subtypes) (P<0.05 or 0.01). High degree BAG- 1 expression in postoperative recurrence cases and no- recurrence cases were 12.50%(3/24) and 76.12%(102/134), respectively(P<0.05). There was no significant difference in expression degree of BAG- 1 between peritumoral edema grade 0 and grade 1 or grade 2 to grade 3 (al P>0.05). But the expression degree of BAG- 1 between peritumoral edema grade 0 or 1 and the grade 2 or 3, the difference had statistical significance (al P<0.05). Conclusion The expressions of BAG- 1 are negatively correlated with peritu-moral edema and postoperative recurrent in meningrioma.