CAJ | 학술논문

目的观察盐酸羟考酮缓释片和芬太尼透皮贴对放射性口腔黏膜炎所致疼痛的止痛效果、患者生活质量改善程度和不良反应.方法将66例鼻咽癌放疗患者随机分为两组,羟考酮组34例,患者初始剂量为10 mg口服,q12h,芬太尼组32例,给予25μg/h(4.2 mg,q72h),根据疼痛情况调整剂量,每3个小时记录一次疼痛程度,每24小时评估生活质量及不良反应.结果两组放射性黏膜炎所致疼痛均有所减轻,在放疗的第5～7周,羟考酮组的止痛效果略优于芬太尼组,第7周(3.59±0.28)vs(4.42±0.33),差异有统计学意义(P＜0.05).两组便秘、恶心呕吐、头晕发生率差异无统计学意义(P＞0.05);两组均无呼吸抑制及成瘾性的发生.结论羟考酮缓释片和芬太尼透皮贴均适用于放射性黏膜炎所致疼痛,疗效确切.放射性黏膜炎所致疼痛随着放疗剂量的增加而逐渐加重,如何既利用羟考酮缓释片加快镇痛的剂量调整,又发挥芬太尼透皮贴剂长效稳定、使用方便、不良反应少的特点,是我们下一步的研究方向.
목적 관찰염산간고동완석편화분태니투피첩대방사성구강점막염소치동통적지통효과、환자생활질량개선정도화불량반응.방법 장66례비인암방료환자수궤분위량조,간고동조34례,환자초시제량위10 mg구복,q12h,분태니조32례,급여25μg/h(4.2 mg,q72h),근거동통정황조정제량,매3개소시기록일차동통정도,매24소시평고생활질량급불량반응.결과 량조방사성점막염소치동통균유소감경,재방료적제5～7주,간고동조적지통효과략우우분태니조,제7주(3.59±0.28)vs(4.42±0.33),차이유통계학의의(P＜0.05).량조편비、악심구토、두훈발생솔차이무통계학의의(P＞0.05);량조균무호흡억제급성은성적발생.결론 간고동완석편화분태니투피첩균괄용우방사성점막염소치동통,료효학절.방사성점막염소치동통수착방료제량적증가이축점가중,여하기이용간고동완석편가쾌진통적제량조정,우발휘분태니투피첩제장효은정、사용방편、불량반응소적특점,시아문하일보적연구방향.
Objective To observe the clinical efficacy of Durogesic and OxyContin in relieving moderate or severe acute radiotheraputic mucositis-induced pain,improving the life quality and adverse drug reactions in patients with nasopharyngeal carcinoma.Method A total of 66 patients with nasopharyngeal carcinoma who severe radiotheraputic mucosi-tisinduced pain was complained during radiotherapy were randomly divided into two groups:34 patients (OxyContin group) were treated with OxyContin plus routine therapy,and 32 patients(Durogesic group) were treated with Durogesic.The pain-relieving efficacy were recorded every 3 hours.The score of life quality and the side effects were recorded every 24 hours.Results There was significant difference between the two groups in radiotheraputic mucositis-induced pain.Conclusion OxyContin is convenient in the control of radiotheraputic mucositis-induced pain because of its rapid action and easy adjustment.