中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
15期
2403-2408
,共6页
周丽斌%吴玮%王佩林%丁瑞英%韩浩伦%李保卫%王刚%王鸿南%赵晋龙%刘彦普
週麗斌%吳瑋%王珮林%丁瑞英%韓浩倫%李保衛%王剛%王鴻南%趙晉龍%劉彥普
주려빈%오위%왕패림%정서영%한호륜%리보위%왕강%왕홍남%조진룡%류언보
组织构建%骨组织工程%下颌骨缺损%钛板%髂骨移植%计算机辅助设计%快速成型%核素骨显像%修复体
組織構建%骨組織工程%下頜骨缺損%鈦闆%髂骨移植%計算機輔助設計%快速成型%覈素骨顯像%脩複體
조직구건%골조직공정%하합골결손%태판%가골이식%계산궤보조설계%쾌속성형%핵소골현상%수복체
mandible%titanium%braces%ilium%bone transplantation%tomography,spiral computed
背景：近年来，快速成型技术被迅速的应用于医学重建领域，利用快速成型技术可为组织缺损患者制作个体化的植入物，可达到空间尺寸上的精确修复。<br> 目的：利用快速成型技术制作个体化钛板，结合自体松质骨移植，修复犬下颌骨节段性缺损。<br> 方法：9只杂种犬行螺旋CT扫描获取头颅骨骼数据，建立数字3D模型，在模型上模拟右侧下颌骨体部切除术，并制作个体化板状修复体，经快速成型加工制造，获得个体化的钛板。然后行动物实验，手术制造右侧下颌骨体部4 cm长节段性缺损，同期手术切取自体髂骨块固定于快速成型钛板的舌侧，修复下颌骨缺损。采用核医学、力学、影像学和组织学等方法评估骨移植后的转归。<br> 结果与结论：应用快速成型支架重建了左右对称的下颌骨形态，自体髂骨移植后逐渐皮质化，植骨和钛板之间形成纤维结缔组织间隔层。在下颌骨缺损修复中，应用快速成型钛板能够达到形态和功能兼顾的效果。
揹景：近年來，快速成型技術被迅速的應用于醫學重建領域，利用快速成型技術可為組織缺損患者製作箇體化的植入物，可達到空間呎吋上的精確脩複。<br> 目的：利用快速成型技術製作箇體化鈦闆，結閤自體鬆質骨移植，脩複犬下頜骨節段性缺損。<br> 方法：9隻雜種犬行螺鏇CT掃描穫取頭顱骨骼數據，建立數字3D模型，在模型上模擬右側下頜骨體部切除術，併製作箇體化闆狀脩複體，經快速成型加工製造，穫得箇體化的鈦闆。然後行動物實驗，手術製造右側下頜骨體部4 cm長節段性缺損，同期手術切取自體髂骨塊固定于快速成型鈦闆的舌側，脩複下頜骨缺損。採用覈醫學、力學、影像學和組織學等方法評估骨移植後的轉歸。<br> 結果與結論：應用快速成型支架重建瞭左右對稱的下頜骨形態，自體髂骨移植後逐漸皮質化，植骨和鈦闆之間形成纖維結締組織間隔層。在下頜骨缺損脩複中，應用快速成型鈦闆能夠達到形態和功能兼顧的效果。
배경：근년래，쾌속성형기술피신속적응용우의학중건영역，이용쾌속성형기술가위조직결손환자제작개체화적식입물，가체도공간척촌상적정학수복。<br> 목적：이용쾌속성형기술제작개체화태판，결합자체송질골이식，수복견하합골절단성결손。<br> 방법：9지잡충견행라선CT소묘획취두로골격수거，건립수자3D모형，재모형상모의우측하합골체부절제술，병제작개체화판상수복체，경쾌속성형가공제조，획득개체화적태판。연후행동물실험，수술제조우측하합골체부4 cm장절단성결손，동기수술절취자체가골괴고정우쾌속성형태판적설측，수복하합골결손。채용핵의학、역학、영상학화조직학등방법평고골이식후적전귀。<br> 결과여결론：응용쾌속성형지가중건료좌우대칭적하합골형태，자체가골이식후축점피질화，식골화태판지간형성섬유결체조직간격층。재하합골결손수복중，응용쾌속성형태판능구체도형태화공능겸고적효과。
BACKGROUND:Rapid prototyping technique has been recently applied in the medical reconstruction and al ows the production of individual implant for patients with tissue defects, achieving an accurate repair. <br> OBJECTIVE:To repair discontinuous mandibular defects in dogs using rapid prototyped titanium plate in combination with autologous cancellous bone graft. <br> METHODS:Nine hybrid canines were used, and the skul was scanned using spiral CT. Then CT data were used to construct three-dimensional digital model, in which virtual partial mandibulectomy was performed, and an individualized bone-grafting plate was designed. A titanium plate was manufactured using rapid prototyping and titanium casting. Animal experiment was then performed. A 40-mm discontinuous defect in the right mandibular body was created in the involved dogs. The defect was restored immediately using the customized plate in combination with autologous cancellous iliac blocks. Sequential radionuclide bone imaging, biomechanical testing, three-dimensional microcomputed tomographic scanning, radiology and histological examination were used to evaluate the turnover of the grafts. <br> RESULTS AND CONCLUSION:A symmetric mandible was reconstructed using the rapid prototyped grafting plate. The grafted bone survived and got corticalized, while a fibrous intermedium was found between the bone graft and the plate. In the reconstruction of mandibular defects, optimal functional and aesthetic outcomes could be achieved using the rapid prototyped grafting plates.
