化学研究与应用
化學研究與應用
화학연구여응용
CHEMICAL RESEARCH AND APPLICATION
2014年
4期
591-595
,共5页
埃索美拉唑钠%奥美拉唑硫醚%埃索美拉唑
埃索美拉唑鈉%奧美拉唑硫醚%埃索美拉唑
애색미랍서납%오미랍서류미%애색미랍서
sodium esomeprazole%ufiprazole%esomeprazole
以不对称氧化反应合成埃索美拉唑钠,优化合成工艺路线。首先制备奥美拉唑硫醚,硫醚再氧化生成埃索美拉唑,最后与氢氧化钠反应制备埃索美拉唑钠。总收率达57.2%,目标化合物的结构经IR、1 H NMR和MS的确证。
以不對稱氧化反應閤成埃索美拉唑鈉,優化閤成工藝路線。首先製備奧美拉唑硫醚,硫醚再氧化生成埃索美拉唑,最後與氫氧化鈉反應製備埃索美拉唑鈉。總收率達57.2%,目標化閤物的結構經IR、1 H NMR和MS的確證。
이불대칭양화반응합성애색미랍서납,우화합성공예로선。수선제비오미랍서류미,류미재양화생성애색미랍서,최후여경양화납반응제비애색미랍서납。총수솔체57.2%,목표화합물적결구경IR、1 H NMR화MS적학증。
Esomeprazole sodium was synthesized through asymmetric oxidation reaction,and the synthesis process route was opti-mized. The ufiprazde was prepared firstly,which then oxidazed to esomeprazole. Finally,the esomeprazole sodium was pepared when esompeprazole reacted with sodium hydroxide. The overall yield was 57. 2%. The structures of target compounds were characterized by IR,1 H NMR and MS.