CAJ | 학술논문

基底细胞癌与毛母细胞瘤在治疗和预后方面有很大的不同。过去由于对两者的分类和诊断比较混乱，给临床治疗带来诸多不便，也给患者增加了不必要的痛苦。这就要求临床医师能及时、准确、有效地鉴别诊断基底细胞癌和毛母细胞瘤。临床上，尤其在病理上，明确鉴别两者很困难。近些年，随着分子生物学技术的发展，从免疫组织化学和遗传学等方面对两者的研究增多，为我们提供一些新的鉴别依据。本文综述几种近年来研究较多的用于两者鉴别诊断的分子生物学标记物AR、CD10、Ln5γ2、Nestin、PHLDAl和CK20的进展。
기저세포암여모모세포류재치료화예후방면유흔대적불동。과거유우대량자적분류화진단비교혼란，급림상치료대래제다불편，야급환자증가료불필요적통고。저취요구림상의사능급시、준학、유효지감별진단기저세포암화모모세포류。림상상，우기재병리상，명학감별량자흔곤난。근사년，수착분자생물학기술적발전，종면역조직화학화유전학등방면대량자적연구증다，위아문제공일사신적감별의거。본문종술궤충근년래연구교다적용우량자감별진단적분자생물학표기물AR、CD10、Ln5γ2、Nestin、PHLDAl화CK20적진전。
Basal cell carcinoma has much difference with trichoblastoma in therapy and prognosis. In the past years, due to the lack of definite classification and distinctions of basal cell carcinoma and trichoblastoma, misdiagnosis and mismanagement were often encountered and the patients underwent inappropriate treatment. So we must differentiate basal cell carcinoma from trichoblastoma early and accurately. It is difficult to distinguish them distinctly only by clinical presentation and pathologic features. In recent years, with the development of molecular biology, research in immunohistochemisty and genetics have increased, and provide us some new identification. This review article mainly describes the recent development of molecular biological markers AR, CD10, Ln5γ2, Nestin, PHLDAl and CK20 for the differential diagnosis of basal cell carcinoma and trichoblastoma.