CAJ | 학술논문

背景：冠状动脉支架置入会造成血管损伤和管壁重构，从而引起血管支架内的再狭窄。研究发现内脏脂肪素与炎性反应相关，在急性心肌梗死斑块破裂处表达增高。目的：观察经皮冠状动脉支架置入后早期对冠状动脉粥样硬化性心脏病患者血清内脏脂肪素水平的影响。方法：选取发病12 h内并行急诊冠状动脉支架置入的急性心肌梗死患者30例，同期选取行冠状动脉支架置入的不稳定性心绞痛和稳定性心绞痛患者各30例；同时选择一组仅行冠状动脉造影无需支架置入治疗患者30例，另选未接受任何处理的健康患者30例作为正常对照组。结果与结论：酶联免疫吸附法检测结果显示，急性心肌梗死组、不稳定型心绞痛组、稳定型心绞痛组置入前及置入后30 min，置入后6，12，24 h各时点脂肪素的浓度持续升高，且均高于正常对照组(P <0.05)。结果证实，冠脉支架置入后24 h内患者血清脏脂肪素水平持续升高。
배경：관상동맥지가치입회조성혈관손상화관벽중구，종이인기혈관지가내적재협착。연구발현내장지방소여염성반응상관，재급성심기경사반괴파렬처표체증고。목적：관찰경피관상동맥지가치입후조기대관상동맥죽양경화성심장병환자혈청내장지방소수평적영향。방법：선취발병12 h내병행급진관상동맥지가치입적급성심기경사환자30례，동기선취행관상동맥지가치입적불은정성심교통화은정성심교통환자각30례；동시선택일조부행관상동맥조영무수지가치입치료환자30례，령선미접수임하처리적건강환자30례작위정상대조조。결과여결론：매련면역흡부법검측결과현시，급성심기경사조、불은정형심교통조、은정형심교통조치입전급치입후30 min，치입후6，12，24 h각시점지방소적농도지속승고，차균고우정상대조조(P <0.05)。결과증실，관맥지가치입후24 h내환자혈청장지방소수평지속승고。
BACKGROUND:Coronary stent implantation can cause blood vessel damage and wal reconstruction, leading to vascular stent restenosis. Studies have found that visfatin is associated with inflammatory reaction, and exhibits an increased expression at the site of plaque rupture in acute myocardial infarction. OBJECTIVE:To investigate the influence of percutaneous coronary intervention on the levels of visfatin in patients with coronary heart disease. METHODS:Thirty patients with acute myocardial infarction within 12 hours after the onset of the chest pain, 30 patients with unstable pectoris and 30 patients with stable angina pectoris were included. Al patients were successfuly treated by percutaneous coronary intervention. Meanwhile, 30 patients only undergoing coronary angiography but not stenting treatment were selected, and another 30 patients without any treatment served as normal control group. RESULTS AND CONCLUSION:According to enzyme-linked immunosorbent method, the visfatin levels of acute myocardial infarction, unstable angina, stable angina and coronary angiography groups continue to rise at pre-operation, 30 minutes, 6 hours, 12 hours, 24 hours after operation, al of which were higher than that in the normal control group (P < 0.05). The results confirmed that within 24 hours after coronary stent implantation the visfatin levels continue to rise.