白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2013年
5期
275-277
,共3页
程辉%邱慧颖%高磊%杨建民%宋献民%黄正霞%许燕群%王健民
程輝%邱慧穎%高磊%楊建民%宋獻民%黃正霞%許燕群%王健民
정휘%구혜영%고뢰%양건민%송헌민%황정하%허연군%왕건민
白血病,早幼粒细胞,急性%融合基因%疗效%预后
白血病,早幼粒細胞,急性%融閤基因%療效%預後
백혈병,조유립세포,급성%융합기인%료효%예후
Leukemia,promyelocytic,acute%Fusion gene%Therapeutic efficacy%Prognosis
目的 探讨急性早幼粒细胞白血病(APL)患者融合基因特点与其疗效、预后及生存的关系.方法 采用荧光定量聚合酶链反应(PCR)的方法对41例形态学初诊为APL患者进行PML-RAR α、PLZF-RAR α融合基因动态监测,比较不同类型融合基因患者达到完全分子生物学缓解(CMR)的时间及患者的生存率、生存时间.结果 41例初诊APL患者,PML-RARα-L型阳性29例,中位年龄43岁(8 ~ 75岁),基因表达水平(60.12±41.24)%,白细胞中位值2.1×109/L(0.44×109/L~ 124× 109/L);PML-RAR α-S阳性11例,中位年龄34岁(19 ~ 66岁),基因表达水平(24.36±25.72)%,白细胞中位值3.2×109/L(0.47×109/L~ 88×109/L);PML-PLZF 1例,基因表达水平较高(64.12%).患者达到完全分子生物学缓解中位时间L型40 d(32~60d),S型56d(25~86d);随访5年无事件生存率分别为100.0%和81.8%(P-0.02);1例PML-PLZF阳性患者18个月内未达到CMR,且存在C-KIT基因突变,形态学复发2次.结论 融合基因PML-RARα-L型APL患者疗效、预后及无事件生存率均好于S型患者,PLZF-RARα基因融合的APL患者易复发且预后较差;APL融合基因分型及预后突变基因的检测,对患者的疗效判定及预后有着非常重要的意义.
目的 探討急性早幼粒細胞白血病(APL)患者融閤基因特點與其療效、預後及生存的關繫.方法 採用熒光定量聚閤酶鏈反應(PCR)的方法對41例形態學初診為APL患者進行PML-RAR α、PLZF-RAR α融閤基因動態鑑測,比較不同類型融閤基因患者達到完全分子生物學緩解(CMR)的時間及患者的生存率、生存時間.結果 41例初診APL患者,PML-RARα-L型暘性29例,中位年齡43歲(8 ~ 75歲),基因錶達水平(60.12±41.24)%,白細胞中位值2.1×109/L(0.44×109/L~ 124× 109/L);PML-RAR α-S暘性11例,中位年齡34歲(19 ~ 66歲),基因錶達水平(24.36±25.72)%,白細胞中位值3.2×109/L(0.47×109/L~ 88×109/L);PML-PLZF 1例,基因錶達水平較高(64.12%).患者達到完全分子生物學緩解中位時間L型40 d(32~60d),S型56d(25~86d);隨訪5年無事件生存率分彆為100.0%和81.8%(P-0.02);1例PML-PLZF暘性患者18箇月內未達到CMR,且存在C-KIT基因突變,形態學複髮2次.結論 融閤基因PML-RARα-L型APL患者療效、預後及無事件生存率均好于S型患者,PLZF-RARα基因融閤的APL患者易複髮且預後較差;APL融閤基因分型及預後突變基因的檢測,對患者的療效判定及預後有著非常重要的意義.
목적 탐토급성조유립세포백혈병(APL)환자융합기인특점여기료효、예후급생존적관계.방법 채용형광정량취합매련반응(PCR)적방법대41례형태학초진위APL환자진행PML-RAR α、PLZF-RAR α융합기인동태감측,비교불동류형융합기인환자체도완전분자생물학완해(CMR)적시간급환자적생존솔、생존시간.결과 41례초진APL환자,PML-RARα-L형양성29례,중위년령43세(8 ~ 75세),기인표체수평(60.12±41.24)%,백세포중위치2.1×109/L(0.44×109/L~ 124× 109/L);PML-RAR α-S양성11례,중위년령34세(19 ~ 66세),기인표체수평(24.36±25.72)%,백세포중위치3.2×109/L(0.47×109/L~ 88×109/L);PML-PLZF 1례,기인표체수평교고(64.12%).환자체도완전분자생물학완해중위시간L형40 d(32~60d),S형56d(25~86d);수방5년무사건생존솔분별위100.0%화81.8%(P-0.02);1례PML-PLZF양성환자18개월내미체도CMR,차존재C-KIT기인돌변,형태학복발2차.결론 융합기인PML-RARα-L형APL환자료효、예후급무사건생존솔균호우S형환자,PLZF-RARα기인융합적APL환자역복발차예후교차;APL융합기인분형급예후돌변기인적검측,대환자적료효판정급예후유착비상중요적의의.
Objective To investigate the relationship of fusion gene characteristics and therapeutic efficacy,prognosis,survival in patients with acute promyelocytic leukemia (APL).Methods dynamicly PML-RARα and PLZF-RARα of 41 newly diagnosed APL patients were monitored with Q-PCR and analyzed.According to patients' fusion gene types,the time reaching complete molecular remission,the patients'survival time and rate were compared and analyzed.Results 29 of 41 newly diagnosed APL patients were observed PML-RARα-L positive,with a median age of 43 years old (8-75 years old),gene expression levels of (60.12±41.24) %,and leukocyte median value of 2.1×109/L [(0.44-124)×109/L].11 of 41 cases were observed PML-RARα-S positive,with a median age of 34 years old (19-66 years old),gene expression levels of (24.36±25.72) %,and leukocyte median value of 3.2×109/L [(0.47-88)×109/L],for just one patient,the gene expression level of PML-PLZF was 64.12 %.The median time reaching complete molecular remission were 40 days (32-60 days) for L-type patients,and 56 days (25-86 days) for S-type patients,the event-free survival rate by 5-year follow-up were 100 % and 81.8 % for L-type and S-type,respectively (P =0.02).The PLZF-RARα-positive patient with C-KIT mutation didn' t have complete molecular remission,morphological relapse occurred two times within 18 months.Conclusions For APL patients with PML-RARα-L,thetherapeutic effect,prognosis,and event-free survival rate are better than APL patients with PML-RARα-S.APL patients with PLZF-RARα are prone to higher relapse and poor prognosis.It' s of high significance to evaluate the therapeutic efficacy and prognosis by detecting fusion gene and possible gene mutations for APL patients.