中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
4期
721-725
,共5页
颜才华%李晓阳%马一杰%罗素霞%陈小兵
顏纔華%李曉暘%馬一傑%囉素霞%陳小兵
안재화%리효양%마일걸%라소하%진소병
癌,非小细胞肺%个体化化疗%靶向治疗
癌,非小細胞肺%箇體化化療%靶嚮治療
암,비소세포폐%개체화화료%파향치료
Carcinoma,non-small-cell lung%Individualized chemotherapy%Targeted therapy
随着对肿瘤细胞生物学、肿瘤分子学、肿瘤药理学等研究的深入,更多化疗药物,尤其是靶向药物的出现,使晚期肺癌的治疗日臻完善。然而近年大量关于肺癌耐药基因及靶向药物的研究,对晚期肺癌“量体裁衣”的个体化治疗提出了挑战。如何为晚期非小细胞肺癌患者制订更准确、有效、毒性更小的个体化治疗方案,是我们亟待解决的问题。
隨著對腫瘤細胞生物學、腫瘤分子學、腫瘤藥理學等研究的深入,更多化療藥物,尤其是靶嚮藥物的齣現,使晚期肺癌的治療日臻完善。然而近年大量關于肺癌耐藥基因及靶嚮藥物的研究,對晚期肺癌“量體裁衣”的箇體化治療提齣瞭挑戰。如何為晚期非小細胞肺癌患者製訂更準確、有效、毒性更小的箇體化治療方案,是我們亟待解決的問題。
수착대종류세포생물학、종류분자학、종류약이학등연구적심입,경다화료약물,우기시파향약물적출현,사만기폐암적치료일진완선。연이근년대량관우폐암내약기인급파향약물적연구,대만기폐암“량체재의”적개체화치료제출료도전。여하위만기비소세포폐암환자제정경준학、유효、독성경소적개체화치료방안,시아문극대해결적문제。
Following the in-depth study of biology, molecular and pharmacology of tumor cell, especially, the emergence of targeted drugs, treatment of advanced lung cancer has been gradual perfection. However, along with the research findings about drug resistance gene in recent years, we met the challenge of individualized treatment of advanced non-small-cell lung carcinoma.The problems to be solved is that we have to face the mission to offer patients with individualized treatment more exactly, more effective and less toxic.