CAJ | 학술논문

背景：干细胞被证明不但具有替代损伤细胞的作用，而且还可以分泌营养因子，为临床脊髓损伤的治疗带来了光明的前景。 　　目的：综述骨髓间充质干细胞在动物实验及临床研究中的最新进展。 　　方法：以“stem cel s, spinal cord injuries, embryonic stem cel s, neural stem cel s, mesenchymal stem cel s”为英文检索词，“干细胞，脊髓损伤，胚胎干细胞，神经干细胞”为中文检索词，应用计算机检索Kjmed数据库和万方医学数据库中2004年4月至2014年4月发表的相关文章。 　　结果与结论：共检索到2745篇，排除无关重复的文献，保留50篇进行综述。骨髓间充质细胞由于其具有众多的优点而受到学术界的广泛青睐，成为脊髓损伤治疗最具前景的干细胞来源之一，虽然脊髓损伤在临床应用上尚处于起步阶段，但是对脊髓损伤的修复作用是肯定的，其作用机制可能与骨髓间充质干细胞的替代作用、神经营养作用、抑制免疫反应及促进轴突再生等有关。
배경：간세포피증명불단구유체대손상세포적작용，이차환가이분비영양인자，위림상척수손상적치료대래료광명적전경。 　　목적：종술골수간충질간세포재동물실험급림상연구중적최신진전。 　　방법：이“stem cel s, spinal cord injuries, embryonic stem cel s, neural stem cel s, mesenchymal stem cel s”위영문검색사，“간세포，척수손상，배태간세포，신경간세포”위중문검색사，응용계산궤검색Kjmed수거고화만방의학수거고중2004년4월지2014년4월발표적상관문장。 　　결과여결론：공검색도2745편，배제무관중복적문헌，보류50편진행종술。골수간충질세포유우기구유음다적우점이수도학술계적엄범청래，성위척수손상치료최구전경적간세포래원지일，수연척수손상재림상응용상상처우기보계단，단시대척수손상적수복작용시긍정적，기작용궤제가능여골수간충질간세포적체대작용、신경영양작용、억제면역반응급촉진축돌재생등유관。
BACKGROUND:Stem cells have been shown to not only replace damaged cells, but also secrete trophic factors, bringing a bright future for the treatment of clinical spinal cord injury. OBJECTIVE:To review the latest advances of bone marrow mesenchymal stem cells in animal and clinical research. METHODS:A computer-based search of Kjmed and Wanfang databases was done for relevant articles published from April 2004 to April 2014 using the keywords of“stem cells, spinal cord injuries, embryonic stem cells, neural stem cells, mesenchymal stem cells”in English and Chinese, respectively. RESULTS AND CONCLUSION:Total y 2 745 articles were initial y retrieved, and only 50 articles were included in result analysis. Bone marrow mesenchymal stem cells have become one of the most promising sources of stem cells in the treatment of spinal cord injury. Although the bone marrow mesenchymal stem cellin the treatment of spinal cord injury is stil in its infancy, it has certain effects on the repair of spinal cord injury. The mechanism of action of bone marrow mesenchymal stem cells in the treatment of spinal cord injury is possibly related to the substitution effect, neurotrophic effects, suppression of the immune response and promoting axonal regeneration.