中华儿科杂志
中華兒科雜誌
중화인과잡지
Chinese Journal of Pediatrics
2014年
10期
729-735
,共7页
超未成熟儿与超低出生体重儿研究协作组%吴繁%崔其亮
超未成熟兒與超低齣生體重兒研究協作組%吳繁%崔其亮
초미성숙인여초저출생체중인연구협작조%오번%최기량
婴儿,新生%婴儿,出生时低体重%存活率%死亡率
嬰兒,新生%嬰兒,齣生時低體重%存活率%死亡率
영인,신생%영인,출생시저체중%존활솔%사망솔
Infant,Newborn%Infant,low birth weight%Survival rate%Mortality rate
目的 探讨广东省新生儿科住院治疗的超未成熟儿(EP)及超低出生体重儿(ELBWI)的存活情况及变化趋势.方法 回顾性分析广东省20家三级甲等综合性医院或妇幼保健院新生儿科2008-2012年出院的888例EP与ELBWI的住院资料.分别计算和比较不同胎龄、出生体重、出院年份、出生地区EP与ELBWI的治愈率与存活率.计数资料组间比较采用x2分析.结果 共888例EP与ELBWI入选该研究,达治愈出院284例(32.0％),转院41例(4.6％),院内死亡178例(20.0％),放弃治疗或提前出院385例(43.4％).放弃治疗或提前出院的385例中,116例(13.1％)存活,269例(30.3％)出院后死亡.2011-2012年与2008-2010年比较,EP与ELBWI在同期新生儿科出院人数的构成比和早产儿出院人数的构成比均呈上升趋势[0.56％(514/92 298)比0.45％(371/82 834),2.01％(514/25 629)比1.63％ (371/22 716),x2=10.318、9.290,P=0.001、0.002];治愈率与存活率增加[37.1％(182/491)比28.7％(102/356),50.1％ (246/491)比43.3％(154/356),x2=6.558、3.878,P=0.010、0.049],病死率降低.EP的总体治愈率和存活率为29.7％(140/471)和38.0％(179/471),而ELBWI的总体治愈率和存活率为31.4％(203/646)和45.8％(296/646).随着出生时胎龄、出生体重的增加,治愈率与存活率增加,病死率降低.广深地区(广州市与深圳市)与广东省其他地区相比,医院治愈率与存活率差异有统计学意义[44.0％(201/457)比21.3％(83/390),51.2％ (234/457)比42.6％(166/390),x2=48.653、6.302,P＜0.001、0.012].结论 EP与ELBWI的救治和存活均有逐年增加趋势,其治愈率、存活率与出生胎龄、出生体重密切相关,广深地区的医院治愈率和存活率高于广东省其他地区.
目的 探討廣東省新生兒科住院治療的超未成熟兒(EP)及超低齣生體重兒(ELBWI)的存活情況及變化趨勢.方法 迴顧性分析廣東省20傢三級甲等綜閤性醫院或婦幼保健院新生兒科2008-2012年齣院的888例EP與ELBWI的住院資料.分彆計算和比較不同胎齡、齣生體重、齣院年份、齣生地區EP與ELBWI的治愈率與存活率.計數資料組間比較採用x2分析.結果 共888例EP與ELBWI入選該研究,達治愈齣院284例(32.0％),轉院41例(4.6％),院內死亡178例(20.0％),放棄治療或提前齣院385例(43.4％).放棄治療或提前齣院的385例中,116例(13.1％)存活,269例(30.3％)齣院後死亡.2011-2012年與2008-2010年比較,EP與ELBWI在同期新生兒科齣院人數的構成比和早產兒齣院人數的構成比均呈上升趨勢[0.56％(514/92 298)比0.45％(371/82 834),2.01％(514/25 629)比1.63％ (371/22 716),x2=10.318、9.290,P=0.001、0.002];治愈率與存活率增加[37.1％(182/491)比28.7％(102/356),50.1％ (246/491)比43.3％(154/356),x2=6.558、3.878,P=0.010、0.049],病死率降低.EP的總體治愈率和存活率為29.7％(140/471)和38.0％(179/471),而ELBWI的總體治愈率和存活率為31.4％(203/646)和45.8％(296/646).隨著齣生時胎齡、齣生體重的增加,治愈率與存活率增加,病死率降低.廣深地區(廣州市與深圳市)與廣東省其他地區相比,醫院治愈率與存活率差異有統計學意義[44.0％(201/457)比21.3％(83/390),51.2％ (234/457)比42.6％(166/390),x2=48.653、6.302,P＜0.001、0.012].結論 EP與ELBWI的救治和存活均有逐年增加趨勢,其治愈率、存活率與齣生胎齡、齣生體重密切相關,廣深地區的醫院治愈率和存活率高于廣東省其他地區.
목적 탐토광동성신생인과주원치료적초미성숙인(EP)급초저출생체중인(ELBWI)적존활정황급변화추세.방법 회고성분석광동성20가삼급갑등종합성의원혹부유보건원신생인과2008-2012년출원적888례EP여ELBWI적주원자료.분별계산화비교불동태령、출생체중、출원년빈、출생지구EP여ELBWI적치유솔여존활솔.계수자료조간비교채용x2분석.결과 공888례EP여ELBWI입선해연구,체치유출원284례(32.0％),전원41례(4.6％),원내사망178례(20.0％),방기치료혹제전출원385례(43.4％).방기치료혹제전출원적385례중,116례(13.1％)존활,269례(30.3％)출원후사망.2011-2012년여2008-2010년비교,EP여ELBWI재동기신생인과출원인수적구성비화조산인출원인수적구성비균정상승추세[0.56％(514/92 298)비0.45％(371/82 834),2.01％(514/25 629)비1.63％ (371/22 716),x2=10.318、9.290,P=0.001、0.002];치유솔여존활솔증가[37.1％(182/491)비28.7％(102/356),50.1％ (246/491)비43.3％(154/356),x2=6.558、3.878,P=0.010、0.049],병사솔강저.EP적총체치유솔화존활솔위29.7％(140/471)화38.0％(179/471),이ELBWI적총체치유솔화존활솔위31.4％(203/646)화45.8％(296/646).수착출생시태령、출생체중적증가,치유솔여존활솔증가,병사솔강저.엄심지구(엄주시여심수시)여광동성기타지구상비,의원치유솔여존활솔차이유통계학의의[44.0％(201/457)비21.3％(83/390),51.2％ (234/457)비42.6％(166/390),x2=48.653、6.302,P＜0.001、0.012].결론 EP여ELBWI적구치화존활균유축년증가추세,기치유솔、존활솔여출생태령、출생체중밀절상관,엄심지구적의원치유솔화존활솔고우광동성기타지구.
Objective With the progress of perinatal medicine and neonatal treatment technology,more and more extremely preterm (EP) and extremely low birth weight infant (ELBWI) survived all over the world.But in our country,there is still lack of survival analysis of large sample survey in this field.This study was designed to survey the survival and mortality rate of EP and ELBWI who were admitted to neonatology departments.Method Clinical data of EP and ELBWI,who were discharged from January 1,2008 to December 31,2012,were collected retrospectively from twenty tertiary neonatology departments in Guangdong province.Comparisons of cure rate and survival rate were made respectively according to gestational age,birth weight,year of discharge and area of birth.Categorical data were analyzed using the chi-square test,and P ＜0.05 was considered statistically significant.Result There were 888 cases of EP and ELBWI enrolled in the study totally; 284 cases(32.0％) were discharged of cure,41 cases(4.6％) were transferred to other hospitals,178 cases (20.0％) died during hospitalization,and 385 cases (43.4％) were discharged without permission or discharged ahead of schedule.Among these 385 cases,116 (13.1％) survived and 269 (30.3％)died after discharge.While the period 2011-2012 compared to 2008-2010,the proportion of EP and ELBWI in all discharged infants [0.56％ (514/92 298)vs.0.45％ (371/82 834),x2 =10.318,P =0.001] and in preterm infants [2.01％ (514/25 629) vs.1.63％ (371/22 716),x2 =9.290,P =0.002] had gone up.The cure rate [37.1％ (182/491)vs.28.7％ (102/356),x2 =6.558,P =0.010] and survival rate [50.1％ (246/491) vs.43.3％ (154/356),x2 =3.878,P =0.049] had increased too.The overall cure rate and survival rate of EP were 29.7％ (140/471) and 38.0％ (179/471).And the overall cure rate and survival rate of ELBWI were 31.4％ (203/646)and 45.8％ (296/646).Along with the increased gestational age and birth weight,the cure rate and survival rate of EP and ELBWI both increased,and mortality rate decreased.The cure rate [44.0％ (201/457)vs.21.3％ (83/390),x2 =48.653,P ＜0.001] and survival rate [51.2％ (234/457)vs.42.6％ (166/390),x2 =6.302,P =0.012] between hospitals of Guangzhou and Shenzhen were higher than those of other cities.Conclusion EP and ELBWI slightly increased in neonatology departments.And the cure rate and survival rate of them increased too.They were closely related to gestational age and birth weight.The cure rate and survival rate in the hospitals of Guangzhou and Shenzhen were higher than those of the other areas of Guangdong province.
