CAJ | 학술논문

猪链球菌病是由猪链球菌引起的一种人畜共患病，不仅给养猪业的健康发展造成极大的危害，还严重威胁着人类的公共卫生安全，已经引起人们的高度重视。目前，发现和鉴定新的毒力因子成为国内外猪链球菌研究的重点。论文主要对猪链球菌相关毒力因子荚膜多糖、溶菌酶释放蛋白、胞外因子、溶血素及近几年新发现的相关毒力因子荚膜唾液酸、Cbp40、VirA、pgdA、T rag、溶血素相关基因、CiaRH、CcpA、T ro A进行综述。通过总结毒力因子对猪链球菌致病机理的影响，以期为猪链球菌病的治疗及疫苗的研制提供理论基础。
저련구균병시유저련구균인기적일충인축공환병，불부급양저업적건강발전조성겁대적위해，환엄중위협착인류적공공위생안전，이경인기인문적고도중시。목전，발현화감정신적독력인자성위국내외저련구균연구적중점。논문주요대저련구균상관독력인자협막다당、용균매석방단백、포외인자、용혈소급근궤년신발현적상관독력인자협막타액산、Cbp40、VirA、pgdA、T rag、용혈소상관기인、CiaRH、CcpA、T ro A진행종술。통과총결독력인자대저련구균치병궤리적영향，이기위저련구균병적치료급역묘적연제제공이론기출。
Porcine streptococcosis ,a zoonotic disease caused by Streptococcus suis ,not only does great harm to the development of pig industry ,but also is an important threat to public health security .Now this disease has caught public attention .In recent years ,the detectioin and identification of new virulence factors has become the focus of research at home and abroad .This paper focused on the relevant virulence factors of Streptococcus suis , such as capsular polysaccharide (CPS ) , muramidase-released protein (MRP) ,extracellular protein factor(EF) ,suilysin(SLY) and new virulence-associated gene sequences and proteins found lately ,containing capsular sialic acid ,Cbp40 ,VirA ,pgd A ,Trag ,hemolsis-related gene , CiaRH ,CcpA ,TroA .This paper summarized the effects of these virulence factors on the mechanisms in pathogenesis of Streptococcus suis ,providing a theoretical basis for the treatments and development of vac-cine .