CAJ | 학술논문

细胞色素P450（CYP450）2J亚家族简称CYP2J ，与其他CYP450亚家族成员不同，主要在肝外系统表达，并参与内源性物质的代谢，特别是花生四烯酸的代谢，通过其代谢产物表氧化二十碳三烯酸在心血管系统和肾脏发挥重要的生理作用。而在外源性物质的代谢中，CYP2J仅在某些抗组胺药的代谢中表现出较高活性。论文根据CYP2J亚家族近年来的研究成果，对其酶特性、代谢活性、基因结构特征和生理作用等方面的共性进行概括，并对其各成员的表达和代谢特征进行综述。
세포색소P450（CYP450）2J아가족간칭CYP2J ，여기타CYP450아가족성원불동，주요재간외계통표체，병삼여내원성물질적대사，특별시화생사희산적대사，통과기대사산물표양화이십탄삼희산재심혈관계통화신장발휘중요적생리작용。이재외원성물질적대사중，CYP2J부재모사항조알약적대사중표현출교고활성。논문근거CYP2J아가족근년래적연구성과，대기매특성、대사활성、기인결구특정화생리작용등방면적공성진행개괄，병대기각성원적표체화대사특정진행종술。
The CYP2J subfamilies which have been found in recent years ,are different from other CYP450 subfamilies ,and are mainly expressed in the extrahepatic system .They are mainly involed in the metabo-lism of endogenous substances ,especially in metabolism of arachidonic acid .T he arachidonic acid metabo-lites ,ex-poxyeicosatrienoic acids ,play an important role in cardiovascular system and kidney .As for xe-nobiotics metabolism ,CYP2J shows higher activities in certain antihistamines .The common characteris-tics of the CYP2J enzymes ,metabolic activities ,gene structure properties and physiological function of CYP2J subfamilies were introduced briefly ,and the expression profile and metabolic characteristics of CYP2J subfamily members were described in detail in this paper .