CAJ | 학술논문

目的：研究依托咪酯丙泊酚混用和单用在无抽搐电休克（ MECT ）治疗的可行性。方法：90例行MECT 治疗的患者随机分成3组，分别应用依托咪酯-丙泊酚混合液（E-P 组）、依托咪酯（E 组）、丙泊酚（P组）麻醉，记录3组治疗中输入电量（CD）、运动发作时间（ESD）、抑制指数（PSI）、抽搐能量指数（SEI）、抽搐一致性指数（SGI），治疗前后以阳性与阴性症状量表（PANSS）和韦氏记忆量表（WMS）评定其精神状况及记忆水平，记录出现的不良反应，所有数据用SPSS 12．0处理。结果：治疗后E-P组ESD、PSI、SEI、SGI、WMS评分、PANSS 减分均高于 P 组（P ＜0．05），CD 显著低于 P 组（P ＜0．05），与 E 组相当（P ＞0．05）；不良反应方面：恶心呕吐、分泌物增多E-P组低于E组（P＜0．05），注射疼E-P组低于P组（P＜0．05）。结论：依托咪酯-丙泊酚混合液应用于MECT麻醉优于两种药物的单独应用。
목적：연구의탁미지병박분혼용화단용재무추휵전휴극（ MECT ）치료적가행성。방법：90례행MECT 치료적환자수궤분성3조，분별응용의탁미지-병박분혼합액（E-P 조）、의탁미지（E 조）、병박분（P조）마취，기록3조치료중수입전량（CD）、운동발작시간（ESD）、억제지수（PSI）、추휵능량지수（SEI）、추휵일치성지수（SGI），치료전후이양성여음성증상량표（PANSS）화위씨기억량표（WMS）평정기정신상황급기억수평，기록출현적불량반응，소유수거용SPSS 12．0처리。결과：치료후E-P조ESD、PSI、SEI、SGI、WMS평분、PANSS 감분균고우 P 조（P ＜0．05），CD 현저저우 P 조（P ＜0．05），여 E 조상당（P ＞0．05）；불량반응방면：악심구토、분비물증다E-P조저우E조（P＜0．05），주사동E-P조저우P조（P＜0．05）。결론：의탁미지-병박분혼합액응용우MECT마취우우량충약물적단독응용。
Objective To explore the feasibility of the mixed- or single-application of etomidate and propofol during modified electroconvulsive therapy (MECT). Methods Ninety hospitalized schizophrenics undergoing MECT were randomly assigned to 3 groups which were respectively anesthetized with mixed liquor application of etomidate and propofol (group E-P), etomidate (E) or propofol (P). Charge delivered (CD), EEG seizure duration (ESD), postictal suppression index (PSI), seizure energy index (SEI) and seizure generalization index (SGI) were recorded. Mental status and memory levels were assessed with the Positive and Negative Syndrome Scale (PANSS) and Wechsler Memory Scale (WMS) before and after treatment. The adverse reactions were recorded. All data were analyzed with the software SPSS12.0. Results The ESD, PSI, SEI, SGI and WMS scores, and the minus score of PANSS were significantly higher (P < 0.05) and CD was lower (P < 0.05) in group E-P than those in group P. No significant alteration between group E-P and group E (P > 0.05). The adverse reactions such as nausea/vomiting and secretion increase in group E-P were lower than those in group E (P < 0.05). The injection pain of group E-P was lower than that of group P (P<0.05). Conclusion The mixed liquor of etomidate and propofol has an advantage over the single-application of the two drugs during MECT.