中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
9期
48-50
,共3页
MMP-2%MMP-9%子宫内膜腺癌%免疫组化%肿瘤%转移
MMP-2%MMP-9%子宮內膜腺癌%免疫組化%腫瘤%轉移
MMP-2%MMP-9%자궁내막선암%면역조화%종류%전이
MMP-2%MMP-9%Endometrial adenocarcinoma%Immunohistochemistry%Neoplasms%Metastasis
目的：探讨基质金属蛋白酶-2、-9（Matrix metalloproteinases，MMP）在子宫内膜腺癌组织中的表达及其与临床病理关系。方法：应用免疫组化SP法检测MMP-2、MMP-9在不同子宫内膜组织中的表达情况。结果：MMP-2在正常子宫内膜、子宫内膜增生症和子宫内膜腺癌组织中的阳性表达率分别为15.0%、26.7%、88.0%， MMP-9的阳性表达率分别为25.0%、33.3%、95.0%，MMP-2和MMP-9的表达在子宫内膜腺癌中均明显高于正常子宫内膜、子宫内膜增生症，比较差异均有统计学意义（P<0.05）。MMP-2、MMP-9的表达强度与子宫内膜腺癌的手术-病理分期、组织学分级、肌层浸润和淋巴结转移相关，差异均有统计学意义（P<0.05）。结论：MMP-2、MMP-9在子宫内膜腺癌的发生、发展过程中起促进作用，且两者表达与子宫内膜腺癌的浸润深度和转移程度有关，为早期诊断子宫内膜腺癌以及子宫内膜腺癌的预后判断、靶向治疗提供了可靠的依据。
目的：探討基質金屬蛋白酶-2、-9（Matrix metalloproteinases，MMP）在子宮內膜腺癌組織中的錶達及其與臨床病理關繫。方法：應用免疫組化SP法檢測MMP-2、MMP-9在不同子宮內膜組織中的錶達情況。結果：MMP-2在正常子宮內膜、子宮內膜增生癥和子宮內膜腺癌組織中的暘性錶達率分彆為15.0%、26.7%、88.0%， MMP-9的暘性錶達率分彆為25.0%、33.3%、95.0%，MMP-2和MMP-9的錶達在子宮內膜腺癌中均明顯高于正常子宮內膜、子宮內膜增生癥，比較差異均有統計學意義（P<0.05）。MMP-2、MMP-9的錶達彊度與子宮內膜腺癌的手術-病理分期、組織學分級、肌層浸潤和淋巴結轉移相關，差異均有統計學意義（P<0.05）。結論：MMP-2、MMP-9在子宮內膜腺癌的髮生、髮展過程中起促進作用，且兩者錶達與子宮內膜腺癌的浸潤深度和轉移程度有關，為早期診斷子宮內膜腺癌以及子宮內膜腺癌的預後判斷、靶嚮治療提供瞭可靠的依據。
목적：탐토기질금속단백매-2、-9（Matrix metalloproteinases，MMP）재자궁내막선암조직중적표체급기여림상병리관계。방법：응용면역조화SP법검측MMP-2、MMP-9재불동자궁내막조직중적표체정황。결과：MMP-2재정상자궁내막、자궁내막증생증화자궁내막선암조직중적양성표체솔분별위15.0%、26.7%、88.0%， MMP-9적양성표체솔분별위25.0%、33.3%、95.0%，MMP-2화MMP-9적표체재자궁내막선암중균명현고우정상자궁내막、자궁내막증생증，비교차이균유통계학의의（P<0.05）。MMP-2、MMP-9적표체강도여자궁내막선암적수술-병리분기、조직학분급、기층침윤화림파결전이상관，차이균유통계학의의（P<0.05）。결론：MMP-2、MMP-9재자궁내막선암적발생、발전과정중기촉진작용，차량자표체여자궁내막선암적침윤심도화전이정도유관，위조기진단자궁내막선암이급자궁내막선암적예후판단、파향치료제공료가고적의거。
Objective:To investigate the expression of MMP-2 and MMP-9 in endometrial adenocarcinoma tissue and its relation to clinical pathological characteristics.Method:Expression of MMP-2 and MMP-9 was examined by immunohistochemistry(SP method)in three different kinds of endometrium.Result:The results showed that the positive rates of MMP-2 in normal endometria,endometrial hyperplasias and endometrial adenocarcinomas were 15.0%,26.7%and 88.0%respectively,the positive rates of MMP-9 were 25.0%,33.3%and 95.0%respectively.Expression of MMP-2 and MMP-9 were significantly higher in endometrial adenocarcinoma than those in hyperplastic and normal endometria, the differences were statistically significant(P<0.05).In endometrial adenocarcinoma tissue,the positive expression of MMP-2 and MMP-9 was correlated with clinical pathological characteristics,histodifferentiation,myometrial invasion and lymphatic metastasis,the differences were statistically significant(P<0.05).Conclusion:MMP-2 and MMP-9 can promote the development and progression of endometrial adenocarcinoma.The expression rate of MMP-2,MMP-9 is related to the malignancy and metastasis degree of endometrioid adenocarcinoma,so the detection of MMP-2,MMP-9 can provide a reliable proof for the early diagnosis and the prognosis and targeted therapy of patients with endometrial adenocarcinoma.
