中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
9期
950-952
,共3页
2型糖尿病%视网膜病变%同型半胱氨酸%血糖
2型糖尿病%視網膜病變%同型半胱氨痠%血糖
2형당뇨병%시망막병변%동형반광안산%혈당
Type 2 diabetes%Diabetic fundus lesions%Homocysteine%Blood glucose
目的 探讨2型糖尿病视网膜病变患者血浆同型半胱氨酸(Hcy)的变化及与血糖水平的相关性.方法 选择2011年2月至2012年10月我院住院治疗的2型糖尿病视网膜病变患者60例作为糖尿病视网膜病变组,选择同期住院的2型糖尿病患者40例作为糖尿病组,同期健康体检者40名作为健康对照组,测定3组研究对象的糖化血红蛋白(HbAlc)、空腹血糖(FBG)、Hcy、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并进行统计学比较.结果 与健康对照组比较,糖尿病伴视网膜病变组与2型糖尿病组患者Hcy[(7.3±1.8)、(17.6±4.7)、(13.3±2.9) μmol/L]、HbAlc[(4.0±1.1)％、(11.3±2.7)％、(9.2±1.4)％]、FBG[(4.2±1.7)、(11.5±3.4)、(10.1 ±2.1)mmol/L]及TC[(4.4±0.8)、(6.7±1.1)、(5.1±1.0) mmol/L]显著升高,差异均有统计学意义(F值分别为5.091、5.107、6.017、5.813,P值分别为0.043、0.036、0.032、0.040)；2型糖尿病视网膜病变患者Hcy、TC、FBG、HbAlc水平随眼底动脉硬化分级增加而升高,各级之间差异均有统计学意义(F值分别为5.418、5.524、4.971、5.713,P值分别为0.038、0.041、0.042、0.040).结论 Hcy与血糖是2型糖尿病视网膜病变的危险因子,降低Hcy和血糖可作为预防2型糖尿病视网膜病变的新途径.
目的 探討2型糖尿病視網膜病變患者血漿同型半胱氨痠(Hcy)的變化及與血糖水平的相關性.方法 選擇2011年2月至2012年10月我院住院治療的2型糖尿病視網膜病變患者60例作為糖尿病視網膜病變組,選擇同期住院的2型糖尿病患者40例作為糖尿病組,同期健康體檢者40名作為健康對照組,測定3組研究對象的糖化血紅蛋白(HbAlc)、空腹血糖(FBG)、Hcy、總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C),併進行統計學比較.結果 與健康對照組比較,糖尿病伴視網膜病變組與2型糖尿病組患者Hcy[(7.3±1.8)、(17.6±4.7)、(13.3±2.9) μmol/L]、HbAlc[(4.0±1.1)％、(11.3±2.7)％、(9.2±1.4)％]、FBG[(4.2±1.7)、(11.5±3.4)、(10.1 ±2.1)mmol/L]及TC[(4.4±0.8)、(6.7±1.1)、(5.1±1.0) mmol/L]顯著升高,差異均有統計學意義(F值分彆為5.091、5.107、6.017、5.813,P值分彆為0.043、0.036、0.032、0.040)；2型糖尿病視網膜病變患者Hcy、TC、FBG、HbAlc水平隨眼底動脈硬化分級增加而升高,各級之間差異均有統計學意義(F值分彆為5.418、5.524、4.971、5.713,P值分彆為0.038、0.041、0.042、0.040).結論 Hcy與血糖是2型糖尿病視網膜病變的危險因子,降低Hcy和血糖可作為預防2型糖尿病視網膜病變的新途徑.
목적 탐토2형당뇨병시망막병변환자혈장동형반광안산(Hcy)적변화급여혈당수평적상관성.방법 선택2011년2월지2012년10월아원주원치료적2형당뇨병시망막병변환자60례작위당뇨병시망막병변조,선택동기주원적2형당뇨병환자40례작위당뇨병조,동기건강체검자40명작위건강대조조,측정3조연구대상적당화혈홍단백(HbAlc)、공복혈당(FBG)、Hcy、총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C),병진행통계학비교.결과 여건강대조조비교,당뇨병반시망막병변조여2형당뇨병조환자Hcy[(7.3±1.8)、(17.6±4.7)、(13.3±2.9) μmol/L]、HbAlc[(4.0±1.1)％、(11.3±2.7)％、(9.2±1.4)％]、FBG[(4.2±1.7)、(11.5±3.4)、(10.1 ±2.1)mmol/L]급TC[(4.4±0.8)、(6.7±1.1)、(5.1±1.0) mmol/L]현저승고,차이균유통계학의의(F치분별위5.091、5.107、6.017、5.813,P치분별위0.043、0.036、0.032、0.040)；2형당뇨병시망막병변환자Hcy、TC、FBG、HbAlc수평수안저동맥경화분급증가이승고,각급지간차이균유통계학의의(F치분별위5.418、5.524、4.971、5.713,P치분별위0.038、0.041、0.042、0.040).결론 Hcy여혈당시2형당뇨병시망막병변적위험인자,강저Hcy화혈당가작위예방2형당뇨병시망막병변적신도경.
Objective To investigate the correlation of homoeysteine (Hcy) and blood glucose level with type 2 diabetic fundus lesions.Methods Sixty patients with type 2 diabetic fundus lesions were selected and grouped as the diabetic fundus lesions group from February of 2011 to October of 2012,and 40 patients with type 2 diabetes were recruited as the diabetes group,40 healthy volunteer were recruited as the control group.Glycosylated hemoglobin Alc(HbAlc),fasting blood glucose(FBG),homocysteine(Hcy) and total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) of the three groupwere measured and compared.Results Compared with the control group,Hcy in the diabetic fundus lesions group and the diabetic group were significantly higher than the control group ((17.6 ± 4.7) μmol/L,(13.3 ± 2.9) μmol/L vs.(7.3 ± 1.8) μmol/L),and as well as HbA1 c ((11.3 ±2.7)％,(9.2±1.4)％ vs.(4.0±1.1)％),FBG ((11.5 ±3.4) μmol/L,(10.1 ±2.1) μmol/Lvs.(4.2 ±1.7) μmol/L)and TC((6.7 ±1.1) mmol/L,(5.1 ±1.0) mmol/L vs.(4.4±0.8) mmol/L) (F=5.091,5.107,6.017,5.813,P =0.043,0.036,0.032,0.040 respectively).The Hcy,TC,TG,FBG and HbAlc of type 2 diabetic fundus lesions with I stage were the lowest,and the stage of type 2 diabetic fundus lesions was relevant with the level of Hcy,TC,TG,FBG and HbAlc,which were different significantly (F =5.418,5.524,4.971,5.713 respectively,P =0.038,0.041,0.042,0.040 respectively).Conclusion The serum Hcy and blood glucose are risk factors to type 2 diabetic nephropathy.Lowering Hcy concentration and reducing the glucose may be a new way to prevent the occurrence of type 2 diabetic nephropathy.
