CAJ | 학술논문

目的：探讨晚期结直肠癌(CRC)血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)水平与总生存期相关性。方法：收治晚期CRC患者78例，回顾性分析患者临床特征、血清CEA及CA19-9水平变化及总生存期。应用单因素和多因素分析临床特征与生存相关性。结果：单因素分析提示原发肿瘤切除术(P=0.034)、单器官转移(P=0.044)、化疗后血清CEA下降≥25%(P=0.000)及血清CA19-9下降≥50%(P=0.001)患者生存期明显延长。多因素分析提示多器官转移(P=0.043)、化疗后血清CEA下降＜25%(P=0.023)及CA19-9下降＜50%(P=0.027)是生存独立预测因子。结论：化疗后血清CEA及CA19-9下降率可预测晚期CRC患者生存。
목적：탐토만기결직장암(CRC)혈청암배항원(CEA)、당류항원19-9(CA19-9)수평여총생존기상관성。방법：수치만기CRC환자78례，회고성분석환자림상특정、혈청CEA급CA19-9수평변화급총생존기。응용단인소화다인소분석림상특정여생존상관성。결과：단인소분석제시원발종류절제술(P=0.034)、단기관전이(P=0.044)、화료후혈청CEA하강≥25%(P=0.000)급혈청CA19-9하강≥50%(P=0.001)환자생존기명현연장。다인소분석제시다기관전이(P=0.043)、화료후혈청CEA하강＜25%(P=0.023)급CA19-9하강＜50%(P=0.027)시생존독립예측인자。결론：화료후혈청CEA급CA19-9하강솔가예측만기CRC환자생존。
Objective:To investigate the correlation of serum carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9 (CA19-9) level of advanced colorectal cancer(CRC) with overall survival.Methods:78 cases with advanced CRC were selected.The clinical characteristics,changes of serum CEA and CA19-9 levels and overall survival were retrospectively analyzed.We analyzed the relationship between clinical features and survival by univariate and multivariate.Results:Single factor analysis showed that the survival time of patients with resection of the primary tumor(P=0.034),single organ metastasis(P=0.044),serum CEA decline≥25% after chemotherapy(P=0.000) and serum CA19-9 decline≥50% (P=0.001) was significantly longer.Multivariate analysis showed that multiple organ metastasis(P=0.043),serum CEA decline<25% after chemotherapy(P=0.023) and CA19-9 decline<50% (P=0.027) were survival independent prognostic factors.Conclusion:Rate of decline of carcinoembryonic antigen and carbohydrate antigen 19-9 after chemotherapy can predict survival in patients with advanced colorectal cancer.