CAJ | 학술논문

目的探讨缺血性脑卒中复发的相关危险因素,为其二级预防提供理论依据.方法登记住院治疗的首次缺血性脑卒中患者612例,随访2年的复发情况,根据是否复发分为复发组和无复发组,记录影响脑卒中复发的各种可能因素,采用Logistic回归模型对这些因素进行分析.结果 612例患者中,复发90例,脑卒中后2年的总复发率为14.7％.复发组年龄、吸烟、高血压、糖尿病、心房颤动及高同型半胱氨酸(Hcy)血症较无复发组明显升高(P＜0.05)；抗血小板药物依从性较无复发组明显降低(P＜0.01).Logistic多因素分析显示缺血性脑卒中复发的独立危险因素包括年龄、吸烟、高血压、糖尿病、心房颤动及高Hcy血症、抗血小板药物依从性与缺血性脑卒中复发相关(OR值=11.14、47.38、53.11、111.12、53.11、40.98、90.12,均P＜0.05).结论年龄、吸烟、高血压、糖尿病、心房颤动及高Hcy血症、抗血小板药物依从性均为缺血性脑卒中复发的独立危险因素,加强对这些因素的干预有助于预防缺血性脑卒中的复发.
목적 탐토결혈성뇌졸중복발적상관위험인소,위기이급예방제공이론의거.방법 등기주원치료적수차결혈성뇌졸중환자612례,수방2년적복발정황,근거시부복발분위복발조화무복발조,기록영향뇌졸중복발적각충가능인소,채용Logistic회귀모형대저사인소진행분석.결과 612례환자중,복발90례,뇌졸중후2년적총복발솔위14.7％.복발조년령、흡연、고혈압、당뇨병、심방전동급고동형반광안산(Hcy)혈증교무복발조명현승고(P＜0.05)；항혈소판약물의종성교무복발조명현강저(P＜0.01).Logistic다인소분석현시결혈성뇌졸중복발적독립위험인소포괄년령、흡연、고혈압、당뇨병、심방전동급고Hcy혈증、항혈소판약물의종성여결혈성뇌졸중복발상관(OR치=11.14、47.38、53.11、111.12、53.11、40.98、90.12,균P＜0.05).결론 년령、흡연、고혈압、당뇨병、심방전동급고Hcy혈증、항혈소판약물의종성균위결혈성뇌졸중복발적독립위험인소,가강대저사인소적간예유조우예방결혈성뇌졸중적복발.
Objective To explore the risk factors of the recurrence of ischemic stroke and to supply theoretical basis for secondary prevention.Methods 612 patients with ischemic stroke were enrolled in the study and they were followed-up for 2 years to record the stroke recurrence.According to whether the recurrent stroke occurred,all the patients were divided into the recurrent group and the non-recurrent group.Logistic regression model was used to analyze the risk factors.Results Of 612 patients,90 patients suffered from recurrent stroke and the recurrence rate after 2 years was 14.7％.In the recurrent group,age,smoking,hypertension,diabetes,fibrillation atrial history and homocysteine level were significantly higher than those in non-recurrent group (P ＜ 0.05),compliance of anti-platelet drugs was significantly lower than that in non-recurrent group (P ＜ 0.01).Multivariate analysis suggested that age,smoking,hypertension,diabetes,atrial fibrillation history,homocysteine level and compliance of anti-platelet drugs were associated with recurrence of ischemic stroke (OR value =11.14,47.38,53.11,111.12,53.11,40.98,90.12,all P ＜ 0.05).Conclusion Age,smoking,hypertension,diabetes,atrial fibrillation history,homocysteine level and compliance of anti-platelet drugs are the independent risk factors of recurrent stroke.To enhance the interference of these risk factors are helpful for preventing the recurrence of stroke.