CAJ | 학술논문

目的观察斑蝥酸钠维生素B6注射液联合介入化疗栓塞治疗肝癌伴乙肝肝硬化的作用.方法将98例确诊为肝癌伴乙肝肝硬化的患者随机分为斑蝥酸钠维生素B6治疗组与对照组.治疗组给予斑蝥酸钠维生素B6注射液50 ml,加入生理盐水250～500 ml第1～10天,静脉滴注,1天1次,并于第2天行静脉滴注前行肝介入化疗栓塞.10天为1个疗程,以2个疗程为1个周期.对照组除了斑蝥酸钠维生素B6注射液外,其他护肝、提高免疫力等药物应用,行肝介入化疗栓塞.2个疗程后评价近期疗效、毒副反应、肝功能和肝纤维化指标.结果 2个疗程后,近期疗效、毒副反应、肝功能和肝纤维化指标,两组比较差异有统计学意义(P＜0.05).结论斑蝥酸钠维生素B6与介入化疗栓塞联合应用治疗肝癌伴乙肝硬化有效且安全.
목적 관찰반모산납유생소B6주사액연합개입화료전새치료간암반을간간경화적작용.방법 장98례학진위간암반을간간경화적환자수궤분위반모산납유생소B6치료조여대조조.치료조급여반모산납유생소B6주사액50 ml,가입생리염수250～500 ml제1～10천,정맥적주,1천1차,병우제2천행정맥적주전행간개입화료전새.10천위1개료정,이2개료정위1개주기.대조조제료반모산납유생소B6주사액외,기타호간、제고면역력등약물응용,행간개입화료전새.2개료정후평개근기료효、독부반응、간공능화간섬유화지표.결과 2개료정후,근기료효、독부반응、간공능화간섬유화지표,량조비교차이유통계학의의(P＜0.05).결론 반모산납유생소B6여개입화료전새연합응용치료간암반을간경화유효차안전.
Objective To observe the effect of sodium cantharindinate and vitamin B6 injection combined with TACE for liver cancer complicated with cirrhosis of HBV.Methods 98 patients diagnosed with liver cancer complicated with liver cirrhosis were randomly divided into a sodium cantharindinate and vitamin B6 treatment group and a control group.The treatment group were treated with 50 ml disodium cantharindinate and vitamin B6 injection and 250-500 ml normal saline on day 1-10 once per day by intravenous drip and received TACE treatment after intravenous infusion day 2 for 10 days as a treatment course.2 treatment courses were a treatment period.Besides disodium cantharindinate and vitamin B6 injection,the control group administrated some other drug protecting liver and improving immunity and received transcatheter interventional chemotherapy and embolization.The short-term efficacies,toxicity,liver function,and indexes of hepatic fibrosis were evaluated after two treatment courses.Results After two treatment courses,there were statistical differences in efficacy,toxicity,liver function and indexes of hepatic fibrosis between the 2 groups.Conclusions Sodium cantharindinate and vitamin B6 injection combined with TACE for liver cancer complicated with cirrhosis of HBV is effective and safe.