CAJ | 학술논문

以甲氧基乙酸甲酯、甲酸乙酯和尿素为原料，经缩合、环化、三氯氧磷氯化、氨水取代得到2-氯-4-氨基-5-甲氧基嘧啶，然后与N-乙氧基羰基异硫氰酸酯反应、盐酸羟胺环化、甲氧基化得到目标产物2-氨基-5,8-二甲氧基[1,2,4]三唑[1,5-c]嘧啶。总收率27.2%。
이갑양기을산갑지、갑산을지화뇨소위원료，경축합、배화、삼록양린록화、안수취대득도2-록-4-안기-5-갑양기밀정，연후여N-을양기탄기이류청산지반응、염산간알배화、갑양기화득도목표산물2-안기-5,8-이갑양기[1,2,4]삼서[1,5-c]밀정。총수솔27.2%。
2,4-dichloro-5-methoxyprimidine was synthesized using methyl methoxyacetate, ethyl formate and diamino-methanal as starting materials, and then 2,4-dichloro-5-methoxyprimidine reacted with ammonium hydroxide to give 2-chloro-4-amine-5-methoxyprimidin. Ethyl[(2-chloro-5-methoxyprimidin-4-yl)amino]carbono-thioylcarbamate was prepared from ethyl isothiocyanatidocarbonate with 2-chloro-4-amine-5-methoxyprimidin in dry acetonitrile solution. The target compound of 2-amino-5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin was obtained from ethyl[(2-chloro-5-methoxyprimi-din-4-yl)amino]carbonothioylcarbamate via cyclization, methoxylation. The total yield was 27.2%.