CAJ | 학술논문

目的:分别研究姜黄素与灵芝孢子对非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)小鼠肝脏载脂蛋白B100(apolipoprotein B100,ApoB100)表达的影响,从基因水平探讨姜黄素及灵芝孢予治疗NAFLD的机制,并对比两种药物的治疗效果.方法:应用RT-PCR方法对比正常组、NAFLD模型组、姜黄素治疗组、灵芝孢子治疗组中肝脏ApoB100的mRNA表达.结果:ApoB100 mRNA在模型组表达增高,而在姜黄素治疗组和灵芝孢子治疗组表达均降低,差异有统计学意义(P＜0.05).姜黄素治疗组与灵芝孢子治疗组比较差异无统计学意义(P＞0.05).结论:NAFLD模型组肝脏中ApoB100 mRNA的表达明显增高；姜黄素和灵芝孢子均可通过降低肝脏中ApoB100 mRNA的表达调节脂代谢；姜黄素与灵芝孢子对于小鼠NAFLD治疗效果无明显差异.
목적:분별연구강황소여령지포자대비주정성지방성간병(non-alcoholic fatty liver disease,NAFLD)소서간장재지단백B100(apolipoprotein B100,ApoB100)표체적영향,종기인수평탐토강황소급령지포여치료NAFLD적궤제,병대비량충약물적치료효과.방법:응용RT-PCR방법대비정상조、NAFLD모형조、강황소치료조、령지포자치료조중간장ApoB100적mRNA표체.결과:ApoB100 mRNA재모형조표체증고,이재강황소치료조화령지포자치료조표체균강저,차이유통계학의의(P＜0.05).강황소치료조여령지포자치료조비교차이무통계학의의(P＞0.05).결론:NAFLD모형조간장중ApoB100 mRNA적표체명현증고；강황소화령지포자균가통과강저간장중ApoB100 mRNA적표체조절지대사；강황소여령지포자대우소서NAFLD치료효과무명현차이.