CAJ | 학술논문

目的：观察甲状腺自身抗体（ ATA ）及促甲状腺激素（ TSH ）对复发性流产（ RSA ）的影响。方法选取我院118例早期妊娠患者进行常规检查甲状腺功能，其中73例既往有过2次以上不明原因的流产史患者作为研究组，并以45例既往无不良妊娠史的育龄妇女作为对照组。结果 RSA患者中甲状腺抗体ATA，TPOAb， TGAb阳性率与对照组相比较，P＜0．05，均有统计学差异；甲状腺抗体阳性且伴有促甲状腺激素（ TSH）≥3．93mIU的流产率为83．33％与单纯性甲状腺抗体阳性的患者流产率23．53％比较，P＜0．05，两组比较有统计学差异。结论甲状腺自身抗体阳性与复发性流产关系密切，TSH升高是流产的危险因子，建议两者为孕早期常规筛查。
목적：관찰갑상선자신항체（ ATA ）급촉갑상선격소（ TSH ）대복발성유산（ RSA ）적영향。방법선취아원118례조기임신환자진행상규검사갑상선공능，기중73례기왕유과2차이상불명원인적유산사환자작위연구조，병이45례기왕무불량임신사적육령부녀작위대조조。결과 RSA환자중갑상선항체ATA，TPOAb， TGAb양성솔여대조조상비교，P＜0．05，균유통계학차이；갑상선항체양성차반유촉갑상선격소（ TSH）≥3．93mIU적유산솔위83．33％여단순성갑상선항체양성적환자유산솔23．53％비교，P＜0．05，량조비교유통계학차이。결론갑상선자신항체양성여복발성유산관계밀절，TSH승고시유산적위험인자，건의량자위잉조기상규사사。
Objective To study thyroid autoantibodies ( ATA) and thyroid stimulating hormone TSH for re-current miscarriage ( RSA) effects.Methods One hundred and eighteen cases of early pregnancy in our hospital for rou-tine examination of thyroid function in patients were chosen ,including 73 cases with a history of more than 2 unexplained miscarriages as the study group ,and 45 cases with no previous history of adverse pregnancy women of childbearing age as a control groups .Results Thyroid antibodies ATA ,TPO-Ab,TG-Ab in RSA patients were differente ,compared with the control group( P<0.05);The abortion rate in patiengts with thyroid antibodies associated with thyroid-stimulating hor-mone(TSH)≥3.93mIU was 83.33%and the abortion rate in simple thyroid antibody positive patients was 23.53%.It showed the significant difference ( P<0 .05 ) .Conclusion Thyroid autoantibodies are related to recurrent miscarriage , and TSH is elevated as a miscarriage risk factors .They are recommend as routine screening of early pregnancy .