CAJ | 학술논문

目的：通过检测子痫前期孕妇血清中中性粒细胞明胶酶相关性脂质运载蛋白（ NGAL）的变化，探讨其与子痫前期（ PE）发病及肾功能损害的关系，以指导临床诊疗。方法选取2012年9月～2013年9月我院收治的重度PE患者60例作为观察组（其中：早发型组30例；晚发型组30例）；正常晚孕妇女60例作为对照组（其中：孕周≤34周30例；孕周＞34周30例），采用酶联免疫吸附法（ELISA）检测血清NGAL水平，应用全自动生化分析仪测定血生化指标及24 h尿蛋白。结果观察组血清中NGAL 的表达均明显高于同期对照组，且早发型组高于晚发型组；PE孕妇血清NGAL水平与血尿酸和24h尿蛋白总量呈正相关（ r＝0．476，0．565，P＜0．01）。结论血清NGAL水平在PE患者中的表达升高，血尿酸和24 h尿蛋白总量升高，推测NGAL可能与肾功能损伤有关，并可能通过不同途径共同参与子痫前期的病理生理过程。末器官的损伤及严重程度的一项生化标志物，从而用以监测母体受累器官的功能状态，以便及时终止妊娠，达到最佳的母婴预后。
목적：통과검측자간전기잉부혈청중중성립세포명효매상관성지질운재단백（ NGAL）적변화，탐토기여자간전기（ PE）발병급신공능손해적관계，이지도림상진료。방법선취2012년9월～2013년9월아원수치적중도PE환자60례작위관찰조（기중：조발형조30례；만발형조30례）；정상만잉부녀60례작위대조조（기중：잉주≤34주30례；잉주＞34주30례），채용매련면역흡부법（ELISA）검측혈청NGAL수평，응용전자동생화분석의측정혈생화지표급24 h뇨단백。결과관찰조혈청중NGAL 적표체균명현고우동기대조조，차조발형조고우만발형조；PE잉부혈청NGAL수평여혈뇨산화24h뇨단백총량정정상관（ r＝0．476，0．565，P＜0．01）。결론혈청NGAL수평재PE환자중적표체승고，혈뇨산화24 h뇨단백총량승고，추측NGAL가능여신공능손상유관，병가능통과불동도경공동삼여자간전기적병리생리과정。말기관적손상급엄중정도적일항생화표지물，종이용이감측모체수루기관적공능상태，이편급시종지임신，체도최가적모영예후。
Objective To detect serum neutrophil gelatinase-associated lipocalin ( Neutrophil gelatinase-as-sociated lipocalin ,NGAL) in preeclampsia ,and to explore relationships between preeclampsia and renal damage to guide clinical diagnosis and treatment .Methods Using enzyme-linked immunosorbent assay detection of severe preeclampsia ( case group:30 patients with early onset and late onset group ,30 cases ) , normal late-pregnant women ( control group:gestational age≤34 weeks control group of 30 cases,gestational age>34 weeks 30 patients ) serum NGAL levels;auto-matic biochemistry analyzer blood biochemical indices and 24 hours proteinuria .Results In the early-onset group and late onset group , serum NGAL expression was significantly higher than the control group , Serum NGAL levels in pre-eclampsia were related with serum uric acid and total urinary protein .Conclusion Serum levels of NGAL expression in-crease in preeclampsia ,and it suggests that NGAL may be associated with renal dysfunction ,and are likely to participate through different pathways in the pathophysiology of preeclampsia .It can be used as assessment of preeclampsia in pa-tients with end-organ damage and the severity of a biochemical marker ,which used to monitor the functional status of the parent organ involved ,so that timely termination of pregnancy ,and maternal can achieve the best outcome .