潍坊医学院学报
濰坊醫學院學報
유방의학원학보
JOURNAL OF WEIFANG MEDICAL COLLEGE
2013年
6期
436-438
,共3页
任静静%朱芸%李明%周卉%昌路艳
任靜靜%硃蕓%李明%週卉%昌路豔
임정정%주예%리명%주훼%창로염
脊柱炎,强直性%白介素23%CRP%ESR%HLA-B27
脊柱炎,彊直性%白介素23%CRP%ESR%HLA-B27
척주염,강직성%백개소23%CRP%ESR%HLA-B27
Ankylosing spondylitis%Interleukin-23%CRP%ESR%HLA-B27
目的:通过对强直性脊柱炎(AS)患者血清中白介素23(IL-23)水平的检测,研究其与AS疾病活动的相关性。方法用酶联免疫吸附法( ELISA)检测60例AS患者和28例健康对照组的血清IL-23水平,分别比较患者组与健康对照组,病情活动组与稳定组,HLA-B27阳性组与阴性组及骶髂关节X线不同分期的IL-23水平,检测AS患者疾病活动性、临床指标( CRP,ESR)、骨破坏程度,探讨其与IL-23水平的相关性。结果 AS组血清IL-23浓度高于健康对照组,差异有显著性(P<0.05),AS患者IL-23的水平活动组高于稳定组,差异具有显著性(P<0.05),AS患者HLA-B27阳性组与阴性组IL-23,CRP,ESR比较差异无显著性(P均>0.05),AS患者血清IL-23水平与C反应蛋白、ESR呈正相关性(r值分别为0.333,0.433;P值均<0.01),IL-23水平与骶髂关节X线破坏程度有关,差异具有显著性( P<0.05)。结论 AS患者血清IL-23水平比健康人升高,与疾病活动性相关,与骨破坏的程度相关,血清IL-23水平可作为AS活动性指标,可反映骨破坏程度。
目的:通過對彊直性脊柱炎(AS)患者血清中白介素23(IL-23)水平的檢測,研究其與AS疾病活動的相關性。方法用酶聯免疫吸附法( ELISA)檢測60例AS患者和28例健康對照組的血清IL-23水平,分彆比較患者組與健康對照組,病情活動組與穩定組,HLA-B27暘性組與陰性組及骶髂關節X線不同分期的IL-23水平,檢測AS患者疾病活動性、臨床指標( CRP,ESR)、骨破壞程度,探討其與IL-23水平的相關性。結果 AS組血清IL-23濃度高于健康對照組,差異有顯著性(P<0.05),AS患者IL-23的水平活動組高于穩定組,差異具有顯著性(P<0.05),AS患者HLA-B27暘性組與陰性組IL-23,CRP,ESR比較差異無顯著性(P均>0.05),AS患者血清IL-23水平與C反應蛋白、ESR呈正相關性(r值分彆為0.333,0.433;P值均<0.01),IL-23水平與骶髂關節X線破壞程度有關,差異具有顯著性( P<0.05)。結論 AS患者血清IL-23水平比健康人升高,與疾病活動性相關,與骨破壞的程度相關,血清IL-23水平可作為AS活動性指標,可反映骨破壞程度。
목적:통과대강직성척주염(AS)환자혈청중백개소23(IL-23)수평적검측,연구기여AS질병활동적상관성。방법용매련면역흡부법( ELISA)검측60례AS환자화28례건강대조조적혈청IL-23수평,분별비교환자조여건강대조조,병정활동조여은정조,HLA-B27양성조여음성조급저가관절X선불동분기적IL-23수평,검측AS환자질병활동성、림상지표( CRP,ESR)、골파배정도,탐토기여IL-23수평적상관성。결과 AS조혈청IL-23농도고우건강대조조,차이유현저성(P<0.05),AS환자IL-23적수평활동조고우은정조,차이구유현저성(P<0.05),AS환자HLA-B27양성조여음성조IL-23,CRP,ESR비교차이무현저성(P균>0.05),AS환자혈청IL-23수평여C반응단백、ESR정정상관성(r치분별위0.333,0.433;P치균<0.01),IL-23수평여저가관절X선파배정도유관,차이구유현저성( P<0.05)。결론 AS환자혈청IL-23수평비건강인승고,여질병활동성상관,여골파배적정도상관,혈청IL-23수평가작위AS활동성지표,가반영골파배정도。
Objective Through the detection of serum Interleukin-23(IL-23)levels of ankylosing spondylitis(AS) patients,to study the correlation between it and AS activity.Methods The levels of serum IL-23 were detected in60 patients with AS and 28 cases from healthy control group with enzyme -linked immunosorbet assay(ELISA).Comparisonswas made among the AS group and healthy control group ,disease activity group and stable group,HLA-B27 positiveand negative group and X-ray of sacroiliac joint in different stages .The correlations of IL-23 with AS disease activity,index(CRP,ESR),bone destruction were detected.Results The serum IL-23 concentration of AS group was higher thanthat of healthy control group,and the difference was statistically significant.The levels of IL-23 in active AS patientsgroup were higher than those in the stable group,the difference was statistically significant.Among AS patients withHLA-B27 positive group and negative group,the levels of IL-23,CRP and ESR had no statistical significance (P >0.05).The serum IL-23 levels of AS patients were positively correlated with CRP ,ESR(r =0.333,0.433;P <0.01).Thedifference was statistically significant between the extent of damage and the level of IL -23 X-ray sacroiliac joint(P <0.05).Conclusion The levels of Serum IL-23 in AS patients are associated with bone destruction and disease activities .The levels of serum IL-23 can be used as AS activity index and can reflect the degree of bone destruction.