CAJ | 학술논문

目的：优选复方大黄灌肠液提取工艺。方法：基于大黄灌肠液组方原则，兼顾芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚和枸橼酸主要指标成分含量和水溶性总煎出物，以加水量、浸泡时间、提取时间和提取次数为考察因素，采用多指标综合评分法，利用正交试验优选复方大黄灌肠液提取工艺条件。结果：最佳提取工艺为加水量为6倍，浸泡10 min，提取60 min，提取3次。结论：该工艺合理可行，稳定可控，可用于制剂的实际生产。
목적：우선복방대황관장액제취공예。방법：기우대황관장액조방원칙，겸고호회대황소、대황산、대황소、대황분、대황소갑미화구연산주요지표성분함량화수용성총전출물，이가수량、침포시간、제취시간화제취차수위고찰인소，채용다지표종합평분법，이용정교시험우선복방대황관장액제취공예조건。결과：최가제취공예위가수량위6배，침포10 min，제취60 min，제취3차。결론：해공예합리가행，은정가공，가용우제제적실제생산。
This study was aimed to optimize extraction techniques of Compound Rhubarb Enema. Based on the for-mula principle of Compound Rhubarb Enema, effects of the amount of water, soaking time, extraction time and fre-quency on each index were studied. The content of Aloe-emodin, Rhein, Emodin, Chrysophanol, Physcion, Citric acid, and water soluble substance were taken into consideration. The best extraction condition was optimized by using the orthogonal test coupled with the multi-index comprehensive evaluation. The results showed that the best condi-tion was soaking for 10 min, extraction time for 60 min, extraction for 3 times; and 6 times of water was added. It was concluded that this preparation techniques were feasible and reliable for the manufacturing process of Compound Rhubarb Enema.