CAJ | 학술논문

目的：评价现代中药免煎颗粒治疗慢性前列腺炎的疗效及安全性。方法：确诊为慢性前列腺炎，且符合中医湿热瘀阻型、肾虚型患者120例，用随机数字表法分为西药组与中药组各60例。Ⅱ、ⅢA型慢性前列腺炎患者服用甲磺酸左氧氟沙星片，每日2次，每次0.2 g。ⅢB型患者服用盐酸特拉唑嗪片2 mg，每晚1次，口服。中药组：湿热瘀阻型患者采用通络清解方（自拟方，主要有萆薢、败酱草、车前子等）治疗；肾虚型患者采用加味五子衍宗丸（主要有菟丝子、杞子、熟地、覆盆子、五味子等）；4周为1疗程。结果：中药组的总有效率明显优于西药组（P<0.05）；在改善前列腺炎NIH-CPSI评分、提高患者生活质量，改善患者症状方面，明显优于西药组；另外，中药可以提升ⅢA型慢性前列腺炎患者前列腺液中的卵磷脂小体（P<0.05）。同时未发现明显毒副反应，结论：中药免煎颗粒治疗慢性前列腺炎具有较好疗效和安全性。
목적：평개현대중약면전과립치료만성전렬선염적료효급안전성。방법：학진위만성전렬선염，차부합중의습열어조형、신허형환자120례，용수궤수자표법분위서약조여중약조각60례。Ⅱ、ⅢA형만성전렬선염환자복용갑광산좌양불사성편，매일2차，매차0.2 g。ⅢB형환자복용염산특랍서진편2 mg，매만1차，구복。중약조：습열어조형환자채용통락청해방（자의방，주요유비해、패장초、차전자등）치료；신허형환자채용가미오자연종환（주요유토사자、기자、숙지、복분자、오미자등）；4주위1료정。결과：중약조적총유효솔명현우우서약조（P<0.05）；재개선전렬선염NIH-CPSI평분、제고환자생활질량，개선환자증상방면，명현우우서약조；령외，중약가이제승ⅢA형만성전렬선염환자전렬선액중적란린지소체（P<0.05）。동시미발현명현독부반응，결론：중약면전과립치료만성전렬선염구유교호료효화안전성。
This study was aimed to evaluate the efficacy and safety of free-frying granules of traditional Chinese medicine(TCM) on treatment of chronic prostatitis. A total of 120 chronic prostatitis patients that were diagnosed with the dampness-heat and blood-stasis syndrome and kidney-deficiency syndrome were divided into the TCM group and western medicine group by random digit table. Category II and ⅢA chronic prostatitis were treated with oral administration of Levofloxacin Mesylate Tablets (0.2 g, bid) and the category ⅢB chronic prostatitis was treated with oral administration of Terazosin Hydrochloride Tablets (2 mg, qd). In the TCM group, the dampness-heat and blood-stasis syndrome was treated with Tongluo Qingjie formula ( which was self-made formula containing Rhizoma Dioscoreae Hypoglaucae, Herba Patriniae, Semen Plantaginis, and etc.) and the kidney-deficiency syndrome was treated with Jiawei Wuzhi Yanzong pills (which containing Semen Cuscutae, Chinese Wolfberry, Radix Rehmanniae Preparata, Fructus Rubi and Schisandra chinensis, and etc.). Four weeks was one course of treatment. The results showed that the total effective rate of TCM group was better than that of western medicine group (P< 0.05). Effect of TCM group was obviously better than that of western medicine group in the improvement of prostatitis NIH-CPSI score, the quality of life and symptoms of the patients. TCM may increase lecithin corpuscle in prostatic fluid of ⅢA chronic prostatitis (P< 0.05). Meanwhile, no obvious toxiferous and side reactions were found. It was concluded that the free-frying granules of TCM have good efficacy and safety in the treatment of chronic prostatitis.