CAJ | 학술논문

目的：研究双夏汤不同洗脱液的镇静催眠作用。方法：通过测定小鼠自主活动和对戊巴比妥钠阈下剂量诱导睡眠的作用，观察双夏汤水煎液、水洗液、20%、70%和95%醇洗液的镇静催眠作用。结果：双夏汤水煎液、20%和95%醇洗液显著降低小鼠的站立次数,分别为78.5%，78.3%和62.5%；双夏汤水洗液和70%醇洗液能显著降低小鼠自主活动次数（P<0.01）、站立次数（P<0.01）和修饰时间（P<0.05）。双夏汤水煎液能明显缩短小鼠睡眠的潜伏期（P<0.05），延长小鼠睡眠时间（P<0.05），增加小鼠的入睡率。双夏汤水洗液能显著缩短小鼠睡眠潜伏期（P<0.05），增加小鼠的入睡率。结论：双夏汤水煎液和水洗液的镇静催眠作用优于醇洗液。
목적：연구쌍하탕불동세탈액적진정최면작용。방법：통과측정소서자주활동화대무파비타납역하제량유도수면적작용，관찰쌍하탕수전액、수세액、20%、70%화95%순세액적진정최면작용。결과：쌍하탕수전액、20%화95%순세액현저강저소서적참립차수,분별위78.5%，78.3%화62.5%；쌍하탕수세액화70%순세액능현저강저소서자주활동차수（P<0.01）、참립차수（P<0.01）화수식시간（P<0.05）。쌍하탕수전액능명현축단소서수면적잠복기（P<0.05），연장소서수면시간（P<0.05），증가소서적입수솔。쌍하탕수세액능현저축단소서수면잠복기（P<0.05），증가소서적입수솔。결론：쌍하탕수전액화수세액적진정최면작용우우순세액。
This article was aimed to study the sedative and hypnotic effects of different eluents of Shuangxiatang (SXT). The effects of SXT water decoction, water eluent, 20%, 70% and 95% alcohol eluent on spontaneous ac-tivity and the sleeping induced by subthreshold dose of pentobarbital sodium were measured. The results showed that the SXT decoction, 20% and 95% alcohol eluent can significantly decrease the number of rearing in mice with the percentage of 78.5%, 78.3% and 62.5%, respectively. SXT water eluent and 70% alcohol eluent can significantly decrease the spontaneous activity of mice (P < 0.01), the number of rearing (P < 0.01) and grooming time (P < 0.05). SXT water decoction can significantly shorten sleep latency (P < 0.05), prolong sleep time (P <0.05), and increase rates of sleeping in mice. SXT water eluent can significantly shorten sleep latency in mice (P< 0.05), increase rates of sleeping in mice. SXT water decoction and water eluent have the sedative and hypnotic effects. And the effects are more than alcohol eluents.