CAJ | 학술논문

脂质的内稳态的平衡机制是复杂的，LXRα、固醇调节元件结合蛋白（SREBP）、Insig -Srebp-Scap途径以及胆固醇自我调节反馈等多种机制均参与到脂质的内在平衡过程中。在高浓度胆固醇的环境下，通过胆固醇负反馈的调整 HMG -CoA 还原酶和 Insig -Srebp-Scap途径来抑制胆固醇的生成，与此同时，高浓度胆固醇通过 LXRα/RXR激活SREBP -1c上调多种参与脂肪酸合成的酶的转录，从而均衡的调整多种脂质水平的上升。而在低浓度胆固醇的环境下，通过Insig -Srebp -Scap途径增加 HMG -CoA 还原酶的生成，并使胆固醇的量维持在机体需求的水平上。机体通过以上机制体现了维持脂质内稳态的平衡能力。
지질적내은태적평형궤제시복잡적，LXRα、고순조절원건결합단백（SREBP）、Insig -Srebp-Scap도경이급담고순자아조절반궤등다충궤제균삼여도지질적내재평형과정중。재고농도담고순적배경하，통과담고순부반궤적조정 HMG -CoA 환원매화 Insig -Srebp-Scap도경래억제담고순적생성，여차동시，고농도담고순통과 LXRα/RXR격활SREBP -1c상조다충삼여지방산합성적매적전록，종이균형적조정다충지질수평적상승。이재저농도담고순적배경하，통과Insig -Srebp -Scap도경증가 HMG -CoA 환원매적생성，병사담고순적량유지재궤체수구적수평상。궤체통과이상궤제체현료유지지질내은태적평형능력。
The balance mechanism of lipid homeostasis is complex ,LXRα ,sterol regulating element binding protein (SREBP) ,Insig -SREBP - Scap pathway and cholesterol homeostasis feedback mechanisms are involved in the process of lipid balance .Under the environ-ment of high concentrations of cholesterol ,cholesterol feedback adjustment of HMG CoA reductase and Insig -Srebp - Scap pathway can reduce the production of cholesterol ,meanwhile high concentrations of cholesterol increase the transcription of multiple enzymes involved in fatty acid synthesis by LXRα/RXR activating Srebp -1c .Thereby these ways can adjust and balance various lipid levels .While under the en-vironment of low concentration of cholesterol ,the generation of HMG CoA reductase is increased to keep the amount of cholesterol in the body's need accordingly .By the above mechanism ,the body reflects the ability of balancing lipid level .