CAJ | 학술논문

目的：比较经微量泵静脉注射异舒吉和硝酸甘油治疗高血压急症的疗效和安全性。方法：选择高血压急症患者72例，随机分为异舒吉组(A组35例)和硝酸甘油组(B组37例)。A组应用异舒吉50 ml(50 mg，3～15 ml/h)直接静脉泵入；B组应用硝酸甘油50 mg加入40 ml生理盐水静脉泵入(2～10 ml/h)；两组患者均根据血压调整注射剂量，并观察用药前后血压及心率的不良反应。结果：两组疗效无显著差异。B组治疗后较治疗前心率明显加快，不良反应的发生率明显高于A组。结论：异舒吉治疗高血压急症的临床疗效与硝酸甘油一致,但不良反应少，安全性高，若条件允许可作为首选。
목적：비교경미량빙정맥주사이서길화초산감유치료고혈압급증적료효화안전성。방법：선택고혈압급증환자72례，수궤분위이서길조(A조35례)화초산감유조(B조37례)。A조응용이서길50 ml(50 mg，3～15 ml/h)직접정맥빙입；B조응용초산감유50 mg가입40 ml생리염수정맥빙입(2～10 ml/h)；량조환자균근거혈압조정주사제량，병관찰용약전후혈압급심솔적불량반응。결과：량조료효무현저차이。B조치료후교치료전심솔명현가쾌，불량반응적발생솔명현고우A조。결론：이서길치료고혈압급증적림상료효여초산감유일치,단불량반응소，안전성고，약조건윤허가작위수선。
Objective: To investigate the effect of Isoket and nitroglycerin by intravenous pumping in the treatment of hypertensive emergency. Methods:Seventy two cases of hypertensive emergency were randomly divided into group A(35 cases) and group B(37 cases). Isoket(50 mg) were applied by intravenous pumping in group A, nitroglycerin(50 mg) were applied by intravenous pumping in group B. Blood pressure, heart rate, adverse reactions were measured at before and 15 min,30 min and 60min after treatment. Results: The effective rate of the two groups in the treatment of hypertensive emergency had no significant difference. The hate rate of group B was faster after treatment. The incidence rate of adverse reactions in group B was higher than group A. Conclusion:The curative effect of Isoket in the treatment of hypertensive emergency is the same as nitroglycerin. It is safe and effective, thereby worthy of clinical promotion.