CAJ | 학술논문

肾小球滤过率(GFR)常以肾动态显像法估算，其定量准确性受到质疑。为改善显像法GFR的定量准确性，回顾分析其计算方法和主要影响因素。在计算过程中，首先需以1～3 min内的双肾放射性计数计算肾脏摄取百分数，再以回归法估算肾脏摄取百分数对应的GFR。显像法GFR主要受肾脏深度、本底校正和采集条件的影响。而Tonnesen公式和Taylor公式均不能够准确预测肾脏深度，以满足显像法肾功能定量的要求。为校正本底计数，多采用积分法(Gates)和双校正法(Rutland-Patlak)两种准确性相仿的估算方法，但二者并不能很好地校正肾脏感兴趣区(ROI)内的软组织和血管内放射性计数。此外，注射剂量和采集条件也可影响显像法GFR的准确性。
신소구려과솔(GFR)상이신동태현상법고산，기정량준학성수도질의。위개선현상법GFR적정량준학성，회고분석기계산방법화주요영향인소。재계산과정중，수선수이1～3 min내적쌍신방사성계수계산신장섭취백분수，재이회귀법고산신장섭취백분수대응적GFR。현상법GFR주요수신장심도、본저교정화채집조건적영향。이Tonnesen공식화Taylor공식균불능구준학예측신장심도，이만족현상법신공능정량적요구。위교정본저계수，다채용적분법(Gates)화쌍교정법(Rutland-Patlak)량충준학성상방적고산방법，단이자병불능흔호지교정신장감흥취구(ROI)내적연조직화혈관내방사성계수。차외，주사제량화채집조건야가영향현상법GFR적준학성。
Glomerular filtration rate (GFR) is usually measured by renography method, whose accuracy has been debated over years. To improve its accuracy, we reviewed methods and influence factors for the measurement. Firstly, renal uptake percentage is calculated based on the radioactivity counts during one to three minutes. And then, GFR is calculated from the percentage based on an already fitted linear regression equation. GFR measurement based on renography is affected by renal depth, background correction and acquisition conditions. The kidney depth, usually computed by Tonnesen or Taylor formula, cannot be predicted accurately to meet the requirement of GFR measurement. To correct background counts, both integral (Gates) and double correction (Rutland-Patlak) methods cannot correct counts in soft tissue and vascular, and have a similar accuracy. Additionally, injection dose and acquisition conditions can also affect the accuracy.