CAJ | 학술논문

目的：探讨地塞米松对自体脂肪颗粒移植成活率、脂肪纤维化及坏死程度的影响。方法将抽脂获得的颗粒脂肪组织经洗涤纯化后分为两组,实验组(A组)加入地塞米松,对照组(B组)不加地塞米松,只加入同等体积的生理盐水,将经过不同处理的两组脂肪分别移植于裸鼠背部皮下,3个月后取出裸鼠皮下的脂肪组织,测量其重量,计算其成活率,并进行HE染色测定脂肪的囊腔数,评价其纤维化及坏死程度。结果湿重测定结果显示实验组脂肪颗粒注射移植的成活率(19.77±2.22)%高于对照组(12.80±1.73)%,两组间差异有统计学意义(P<0.01)。HE染色结果显示实验组脂肪的囊腔数(209.68±16.74)显著高于对照组(11.72±1.11),两组间差异有统计学意义(P<0.01)。结论地塞米松可以提高颗粒脂肪移植后的成活率,并能有效降低注射脂肪的纤维化和坏死程度。
목적：탐토지새미송대자체지방과립이식성활솔、지방섬유화급배사정도적영향。방법장추지획득적과립지방조직경세조순화후분위량조,실험조(A조)가입지새미송,대조조(B조)불가지새미송,지가입동등체적적생리염수,장경과불동처리적량조지방분별이식우라서배부피하,3개월후취출라서피하적지방조직,측량기중량,계산기성활솔,병진행HE염색측정지방적낭강수,평개기섬유화급배사정도。결과습중측정결과현시실험조지방과립주사이식적성활솔(19.77±2.22)%고우대조조(12.80±1.73)%,량조간차이유통계학의의(P<0.01)。HE염색결과현시실험조지방적낭강수(209.68±16.74)현저고우대조조(11.72±1.11),량조간차이유통계학의의(P<0.01)。결론지새미송가이제고과립지방이식후적성활솔,병능유효강저주사지방적섬유화화배사정도。
Objective To explore the influence of dexamethasone on the survival rate, fat fibrosis and necrosis degree of fat particle autologous. Methods Fat particle after washed from human liposuction were randomly divided into two groups:group A and group B. Dexamethasone were added as experimental group(group A), and the same volume of saline added as control group(group B). Two Groups of fat particle were respectively transplanted on the back of nude mice. Three months later, took out the fat in subcutaneous tissue to measure the weight and calculation survival rate and HE staining for the determination of fat fibrosis and necrosis degree. Results The fat particle auto-transplantation survival rate (19.77±2.22)%in experimental group was higher than that in control group (12.80±1.73)% the differences between the two groups were significant(P<0.01). After HE staining, the number of vesicles(209.68±16.74)in experimental group was higher than that in control group(11.72±1.11), the differences between the two groups were significant(P<0.01). Conclusion Dexamethasone can raise survival rate of fat particle autologous, and decrease fat fibrosis and necrosis degree.