CAJ | 학술논문

肝纤维化是在肝脏发生广泛坏死或凋亡时，对肝脏慢性损伤的内在性反应，以保持器官的完整性。随着持续的损伤，肝纤维化可以逐渐发展为过度的疤痕化和不可逆的肝功能损伤，即肝硬化。在近二三十年以来，人们在肝纤维化的发病机制方面的研究已经取得了广泛的进展，本文主要注重于在特定的细胞类型及其功能方面阐述肝纤维化的发生及发展原理，以及进一步探讨有关肝纤维化的临床评估和治疗的进展，比如新型的血清学标志物等。肝纤维化的发病机制和诊疗技术所取得的重大发现，必将给广大肝病患者的抗纤维化的彻底治愈提供巨大的帮助。
간섬유화시재간장발생엄범배사혹조망시，대간장만성손상적내재성반응，이보지기관적완정성。수착지속적손상，간섬유화가이축점발전위과도적파흔화화불가역적간공능손상，즉간경화。재근이삼십년이래，인문재간섬유화적발병궤제방면적연구이경취득료엄범적진전，본문주요주중우재특정적세포류형급기공능방면천술간섬유화적발생급발전원리，이급진일보탐토유관간섬유화적림상평고화치료적진전，비여신형적혈청학표지물등。간섬유화적발병궤제화진료기술소취득적중대발현，필장급엄대간병환자적항섬유화적철저치유제공거대적방조。
Liver fibrosis is the intrinsic action to the chronic damage of the liver when the intensive necrosis or apoptosis to keep the organic integrity.As the dangerous factors keep on staying,it can induce the excessive scarring and irreversible hepatic fuction injury,liver cirrhosis.It has been greatly improved in the study of pathogenesis of liver fibrosis in past decades.In this paper,the cytological mechanism of the special cellular types and their functions in proceeding liver fibrosis wil be discussed,and the clinic asessment and the progression of liver fibrosis is also to be evaluated furtherly,such as the new serum biamarkers and so on.These findings both in the mechanism and the therapy of liver Fibrosis must be helpful to the thoroughly ecovery in patients with chronic liver disease.