CAJ | 학술논문

目的：探讨18氟标记的脱氧葡萄糖正电子发射计算机断层显像（fluorie-18 fluorodeoxyglucose positron emission tomography，18 F-FDG PEC/CT）在弥漫大B细胞淋巴瘤化疗中期疗效中的临床应用价值。方法分析经病理确诊的42例弥漫大B细胞淋巴瘤化疗中期18 F-FDG PET/CT显像结果；42例患者均在治疗前和化疗2～4个周期后行18 F-FDG PET/CT显像，图像分析采用视图分析及测量病灶最大摄取值方法相结合。42例患者在化疗6个周期后根据影像学诊断结果和临床医师综合判断分为有效组和无效组，有效组31例，无效组11例。本研究所有数据采用 SPSS17．0统计软件进行统计学分析并评价 qSUVmax（化疗前 SUVmax）、zSUVmax（化疗中期即2～4个疗程后）以及△SUVmax（化疗前与化疗中期的 SUVmax差值）。结果（1）两组患者年龄、性别、临床分期与化疗前SUVmax值差异均无统计学意义。（2）两组间的zSUVmax、△SUVmax化疗中SUVmax值、△SUVmax差异均有统计学意义；相比治疗前，有效组的zSUVmax水平低，呈下降趋势；无效组的 zSUVmax水平高，呈上升趋势。△SUVmax有效组呈下降趋势，无效组呈上升趋势。（3）△SUVmaxROC曲线显示曲线下面积0．918（P ＜0．01），差异均有统计学意义。结论在化疗中期对弥漫大B细胞淋巴瘤的患者行18 F-FDG PET/CT显像对临床疗效的评价有较大的临床应用价值。
목적：탐토18불표기적탈양포도당정전자발사계산궤단층현상（fluorie-18 fluorodeoxyglucose positron emission tomography，18 F-FDG PEC/CT）재미만대B세포림파류화료중기료효중적림상응용개치。방법분석경병리학진적42례미만대B세포림파류화료중기18 F-FDG PET/CT현상결과；42례환자균재치료전화화료2～4개주기후행18 F-FDG PET/CT현상，도상분석채용시도분석급측량병조최대섭취치방법상결합。42례환자재화료6개주기후근거영상학진단결과화림상의사종합판단분위유효조화무효조，유효조31례，무효조11례。본연구소유수거채용 SPSS17．0통계연건진행통계학분석병평개 qSUVmax（화료전 SUVmax）、zSUVmax（화료중기즉2～4개료정후）이급△SUVmax（화료전여화료중기적 SUVmax차치）。결과（1）량조환자년령、성별、림상분기여화료전SUVmax치차이균무통계학의의。（2）량조간적zSUVmax、△SUVmax화료중SUVmax치、△SUVmax차이균유통계학의의；상비치료전，유효조적zSUVmax수평저，정하강추세；무효조적 zSUVmax수평고，정상승추세。△SUVmax유효조정하강추세，무효조정상승추세。（3）△SUVmaxROC곡선현시곡선하면적0．918（P ＜0．01），차이균유통계학의의。결론재화료중기대미만대B세포림파류적환자행18 F-FDG PET/CT현상대림상료효적평개유교대적림상응용개치。
Objectives To explore the clinical value of 18 F-FDG PET/CT in patients with diffuse large B cell lymphoma in their chemotherapy interim.Methods The clinical PET/CT scan data of 42 patients patho-logically proven with DLBCL were analyzed by view analysis,combined with lesions maximum value measuring.42 patients were given the 18 F-FDG PET/CT imaging before the treatment and after 2-4 chemotherapy cycles and they were divided into valid group (31 patients)and invalid group(11 patients) according to the imaging diagnosis and clinical physicians′comprehensive j udgment after 6 cycles of chemo-therapy.SPSS17.0 statistical processing software was adopted to evaluate qSUVmax (SUVmax before chemotherapy),zSUVmax(mid chemotherapy,after 2-4 chemotherapy cycles)and △SUVmax(the difference between qSUVmax and zSUVmax).Results The SUVmax values before the chemotherapy in two groups had no statistically significant difference in terms of age,sex,clinical stage;zSUVmax value,delta SUVmax,and SUVmax in two groups had statistical significance in chemotherapy;Compared with the pretreatment,the SUVmax level in the valid group was low and on the decline,the SUVmax level in invalid group was high and on the rise.Delta SUVmax also showed that valid group was on the decline,in-valid group was on the rise;The SUVmax ROC curve displayed the area of 0.918 under the curve (P <0.01),which were statistically significant.Conclusion In the middle of chemotherapy for DLBCL patients,18 F-FDG PET/CT imaging had a great clinical applied value in the evaluation of clinical curative effect.