新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2014年
5期
610-611
,共2页
丹参多酚酸盐注射液%肺栓塞%疗效
丹參多酚痠鹽註射液%肺栓塞%療效
단삼다분산염주사액%폐전새%료효
salvianolate inj ection%pulmonary embolism%curative effect
目的:探讨丹参多酚酸盐注射液对血流动力学稳定的急性肺栓塞患者的疗效及安全性。方法按肺栓塞中危、低危标准将患者分为中危组(90例)和低危组(30例),每组再随机分为试验组和对照组,通过监测、对比试验组(常规抗凝治疗同时5%葡萄糖注射液250 mL+丹参多酚酸盐注射液200 mg 静点,1日1次共静点14 d)、对照组(仅常规抗凝)治疗前、后D-二聚体、脑钠肽、肺动脉压的差值,对比两组治疗后肺动脉完全再通率、有无出血风险等指标。结果中危试验组脑钠肽、D-二聚体、肺动脉压治疗前、后差值较对照组高(P <0.05),试验组治疗后肺动脉完全再通率较对照组治疗后高(P <0.05);而低危试验组 D-二聚体治疗前后差值较对照组高(P<0.05),试验组治疗后肺动脉完全再通率与对照组治疗后完全再通率比较,差异无统计学意义(P >0.05),中危、低危试验组、对照组均无出血病例。结论丹参多酚酸盐对中危急性肺栓塞患者有明显疗效,且安全。
目的:探討丹參多酚痠鹽註射液對血流動力學穩定的急性肺栓塞患者的療效及安全性。方法按肺栓塞中危、低危標準將患者分為中危組(90例)和低危組(30例),每組再隨機分為試驗組和對照組,通過鑑測、對比試驗組(常規抗凝治療同時5%葡萄糖註射液250 mL+丹參多酚痠鹽註射液200 mg 靜點,1日1次共靜點14 d)、對照組(僅常規抗凝)治療前、後D-二聚體、腦鈉肽、肺動脈壓的差值,對比兩組治療後肺動脈完全再通率、有無齣血風險等指標。結果中危試驗組腦鈉肽、D-二聚體、肺動脈壓治療前、後差值較對照組高(P <0.05),試驗組治療後肺動脈完全再通率較對照組治療後高(P <0.05);而低危試驗組 D-二聚體治療前後差值較對照組高(P<0.05),試驗組治療後肺動脈完全再通率與對照組治療後完全再通率比較,差異無統計學意義(P >0.05),中危、低危試驗組、對照組均無齣血病例。結論丹參多酚痠鹽對中危急性肺栓塞患者有明顯療效,且安全。
목적:탐토단삼다분산염주사액대혈류동역학은정적급성폐전새환자적료효급안전성。방법안폐전새중위、저위표준장환자분위중위조(90례)화저위조(30례),매조재수궤분위시험조화대조조,통과감측、대비시험조(상규항응치료동시5%포도당주사액250 mL+단삼다분산염주사액200 mg 정점,1일1차공정점14 d)、대조조(부상규항응)치료전、후D-이취체、뇌납태、폐동맥압적차치,대비량조치료후폐동맥완전재통솔、유무출혈풍험등지표。결과중위시험조뇌납태、D-이취체、폐동맥압치료전、후차치교대조조고(P <0.05),시험조치료후폐동맥완전재통솔교대조조치료후고(P <0.05);이저위시험조 D-이취체치료전후차치교대조조고(P<0.05),시험조치료후폐동맥완전재통솔여대조조치료후완전재통솔비교,차이무통계학의의(P >0.05),중위、저위시험조、대조조균무출혈병례。결론단삼다분산염대중위급성폐전새환자유명현료효,차안전。
Objective To verify efficacy and safety of salvianolate injection in hemodynamically stable pa-tients with acute pulmonary embolism.Methods According to the risk stratification in pulmonary embol-ism,patients were divided into two big groups:90 cases of moderate risk and 30 cases of low risk.Each group was randomly divided into experimental group and control group.The D-value of D-dime,brain na-triuretic peptide,pulmonary artery pressure,complete recanalization rate of pulmonary artery,bleeding rate of the experimental group (routine anticoagulation treatment at the same time 250 mL 5% glucose+salvianolate injection of 200 mg qd×14 days)and the control group (conventional anticoagulant only)were monitored and compared before and after treatment.Results D-value of D-dimer, brain natriuretic peptide,pulmonary artery pressure of moderate group were higher than those of control group (P<0.05). The complete recanalization rate of pulmonary artery after treatment in the experimental group was higher than that of control group (P<0.05).D-value of D-dimer in low-risk group was higher than that of control group (P <0.05).The complete recanalization rate of pulmonary artery was not statistically significant. Both of the two groups had no hemorrhage cases.Conclusion Salvianolate inj ection is obviously effective and safe in moderate-risk patients with acute pulmonary embolism.