中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2013年
22期
32-33,45
,共3页
肾小球疾病%临床表现%病理特点
腎小毬疾病%臨床錶現%病理特點
신소구질병%림상표현%병리특점
Glomerular disease%Clinical manifestations%Pathological features
目的：探讨肾小球疾病临床与病理特点。方法回顾性分析2010年1月～2013年6月在我院收治的成人肾小球疾病116例患者的临床病例资料，所有患者均经肾活检确诊为肾小球疾病，分析其肾脏病理类型，以及病理与临床表现的关系。结果116例成人肾小球疾病患者中84例患者为原发性肾小球疾病，占72.4%；32例患者为继发性肾小球疾病，占27.6%。其中IgA肾病是原发性肾小球肾炎的主要病理类型，占39.8%。对于肾病综合征、肾炎综合征的患者，不伴有肾小管间质损害的患者与伴有肾小管间质损害的患者相比，两组间尿白蛋白，血肌酐、血尿酸之间的差异具有统计学意义（P＜0.05）。结论肾小球疾病中以原发性肾小球肾炎最为常见，其中IgA肾病是原发性肾小球肾炎最常见的病理类型；而狼疮性肾炎是成人继发性肾小球肾炎最常见的病理类型。不同的肾小球疾病病理类型可有不同的临床表现，尿白蛋白、血肌酐、血尿酸在肾小球疾病的肾小管间质损害中起着一定作用。
目的：探討腎小毬疾病臨床與病理特點。方法迴顧性分析2010年1月～2013年6月在我院收治的成人腎小毬疾病116例患者的臨床病例資料，所有患者均經腎活檢確診為腎小毬疾病，分析其腎髒病理類型，以及病理與臨床錶現的關繫。結果116例成人腎小毬疾病患者中84例患者為原髮性腎小毬疾病，佔72.4%；32例患者為繼髮性腎小毬疾病，佔27.6%。其中IgA腎病是原髮性腎小毬腎炎的主要病理類型，佔39.8%。對于腎病綜閤徵、腎炎綜閤徵的患者，不伴有腎小管間質損害的患者與伴有腎小管間質損害的患者相比，兩組間尿白蛋白，血肌酐、血尿痠之間的差異具有統計學意義（P＜0.05）。結論腎小毬疾病中以原髮性腎小毬腎炎最為常見，其中IgA腎病是原髮性腎小毬腎炎最常見的病理類型；而狼瘡性腎炎是成人繼髮性腎小毬腎炎最常見的病理類型。不同的腎小毬疾病病理類型可有不同的臨床錶現，尿白蛋白、血肌酐、血尿痠在腎小毬疾病的腎小管間質損害中起著一定作用。
목적：탐토신소구질병림상여병리특점。방법회고성분석2010년1월～2013년6월재아원수치적성인신소구질병116례환자적림상병례자료，소유환자균경신활검학진위신소구질병，분석기신장병리류형，이급병리여림상표현적관계。결과116례성인신소구질병환자중84례환자위원발성신소구질병，점72.4%；32례환자위계발성신소구질병，점27.6%。기중IgA신병시원발성신소구신염적주요병리류형，점39.8%。대우신병종합정、신염종합정적환자，불반유신소관간질손해적환자여반유신소관간질손해적환자상비，량조간뇨백단백，혈기항、혈뇨산지간적차이구유통계학의의（P＜0.05）。결론신소구질병중이원발성신소구신염최위상견，기중IgA신병시원발성신소구신염최상견적병리류형；이랑창성신염시성인계발성신소구신염최상견적병리류형。불동적신소구질병병리류형가유불동적림상표현，뇨백단백、혈기항、혈뇨산재신소구질병적신소관간질손해중기착일정작용。
Objective To investigate and analyze the clinical and pathological features of glomerular disease. Methods The clinical data of 116 cases with adult glomerular disease collected in our hospital during January 2010 to June 2013 were retrospectively analyzed. All patients were diagnosed glomerular disease by renal biopsy. The type of renal pathology and the relationship between pathology and clinical manifestations were analyzed. Results In 116 cases with adult glomerular disease,there were 84 patients with primary glomerular disease that accounted for 72.4%,and 32 patients with secondary glomerular disease that accounted for 27.6%. Of which IgA nephropathy was a major pathological type of primary glomerulonephritis and accounted for 39.8%. For the patients with nephrotic syndrome and nephritic syndrome,the differences were statistically significant in urinary albumin,serum creatinine,blood uric acid between the patients with and without tubulointerstitial damage(P < 0.05). Conclusion Primary glomerulonephritis is most common in glomerular disease, of which IgA nephropathy is most common pathological type of primary glomerulonephritis; while lupus nephritis is most common pathological type of adults secondary glomerulonephritis. Different pathology types of glomerular disease may have different clinical manifestations.Urinary albumin, serum creatinine, blood uric acid play a role in the tubulointerstitial damage of glomerular disease.
