浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
23期
2096-2098
,共3页
阿尔茨海默病%血管性痴呆%同型半胱氨酸%胆碱酯酶
阿爾茨海默病%血管性癡呆%同型半胱氨痠%膽堿酯酶
아이자해묵병%혈관성치태%동형반광안산%담감지매
Alzheimer's disease%Vascular dementia%Homocysteine%Cholinesterase
目的：探讨阿尔茨海默病（AD）与血管性痴呆（VD）患者血清同型半胱氨酸（Hcy）及胆碱酯酶（CHE）水平变化的临床意义。方法分别检测62例AD患者、49例VD患者与50例正常老年人（空腹）血清中Hcy及CHE水平。结果 AD组Hcy水平为（18.33±4.85）μmol/L，VD组为（27.52±8.78）μmol/L，正常对照组为（13.47±2.96）μmol/L，AD组、VD组的Hcy水平与正常对照组的比较差异有统计学意义（P＜0.05），VD组与AD组的比较差异有统计学意义（P＜0.05）。AD组CHE水平为（3056±1022）U/L ， VD组为（7564±1889）U/L，正常对照组为（7758±2071）U/L，AD组与正常对照组的比较差异有统计学意义（P＜0.05），AD组与VD组的比较差异有统计学意义（P＜0.05），VD组与正常对照组的比较差异无统计学意义（P＞0.05）。结论 AD与VD患者血清Hcy水平升高与其发病有关，可能是痴呆的危险因素之一；AD患者CHE水平较正常老年人低，可作为AD的一种辅助诊断指标。
目的：探討阿爾茨海默病（AD）與血管性癡呆（VD）患者血清同型半胱氨痠（Hcy）及膽堿酯酶（CHE）水平變化的臨床意義。方法分彆檢測62例AD患者、49例VD患者與50例正常老年人（空腹）血清中Hcy及CHE水平。結果 AD組Hcy水平為（18.33±4.85）μmol/L，VD組為（27.52±8.78）μmol/L，正常對照組為（13.47±2.96）μmol/L，AD組、VD組的Hcy水平與正常對照組的比較差異有統計學意義（P＜0.05），VD組與AD組的比較差異有統計學意義（P＜0.05）。AD組CHE水平為（3056±1022）U/L ， VD組為（7564±1889）U/L，正常對照組為（7758±2071）U/L，AD組與正常對照組的比較差異有統計學意義（P＜0.05），AD組與VD組的比較差異有統計學意義（P＜0.05），VD組與正常對照組的比較差異無統計學意義（P＞0.05）。結論 AD與VD患者血清Hcy水平升高與其髮病有關，可能是癡呆的危險因素之一；AD患者CHE水平較正常老年人低，可作為AD的一種輔助診斷指標。
목적：탐토아이자해묵병（AD）여혈관성치태（VD）환자혈청동형반광안산（Hcy）급담감지매（CHE）수평변화적림상의의。방법분별검측62례AD환자、49례VD환자여50례정상노년인（공복）혈청중Hcy급CHE수평。결과 AD조Hcy수평위（18.33±4.85）μmol/L，VD조위（27.52±8.78）μmol/L，정상대조조위（13.47±2.96）μmol/L，AD조、VD조적Hcy수평여정상대조조적비교차이유통계학의의（P＜0.05），VD조여AD조적비교차이유통계학의의（P＜0.05）。AD조CHE수평위（3056±1022）U/L ， VD조위（7564±1889）U/L，정상대조조위（7758±2071）U/L，AD조여정상대조조적비교차이유통계학의의（P＜0.05），AD조여VD조적비교차이유통계학의의（P＜0.05），VD조여정상대조조적비교차이무통계학의의（P＞0.05）。결론 AD여VD환자혈청Hcy수평승고여기발병유관，가능시치태적위험인소지일；AD환자CHE수평교정상노년인저，가작위AD적일충보조진단지표。
Objective To investigate the clinical significance of the changes of serum concentration of Homocysteine (Hcy) and Cholinesterase(CHE) in patients with Alzheimer's disease(AD) and Vascular dementia(VD). Methods The serum con-centration of Hcy and CHE in patients with AD(n=62) and VD(n=49) were measured after fasting for at least 8 hours, and the re-sults were compared with healthy old people (n=50). Results The serum concentration of Hcy was higher in both patients with AD[(18.33±4.85)μmol/L] and VD [(27.52±8.78)μmol/L] than healthy old people [(13.47±2.96)μmol/L, P<0.05]. Compared with patients with AD, the concentration of Hcy was much higher in patients with VD (P<0.05). However, patients with AD [(3056± 1022) U/L] had apparently lower serum concentration of CHE than healthy old people [(7564 ±1889) U/L] as wel as patients with VD [(7758±2071)U/L, P<0.05], meanwhile there was no obviously difference between VD patients and healthy old people (P>0.05). Conclusion High level of Hcy may be an important risk factor at the onset of AD and VD, while low concentration of CHE might be used as indicator in diagnosis of AD.
