CAJ | 학술논문

目的：评价补肾化痰方联合盐酸多奈哌齐对中重度阿尔茨海默病（AD）伴精神行为症状（BPSD）的疗效及安全性。方法将127例AD患者按照随机数字表法分为研究组62例和对照组65例，研究组患者服用补肾化痰代表方复方海蛇胶囊和盐酸多奈哌齐，对照组患者单用盐酸多奈哌齐；观察12周。治疗前及治疗12周末分别采用痴呆行为量表（BEHAVE- AD）评价精神行为症状，严重障碍量表（SIB）评定患者的认知功能。结果治疗12周末，研究组BEHAVE- AD分值下降较对照组更显著（P＜0.01）；研究组治疗后SIB评分与对照组的差异有统计学意义（P＜0.01）；研究组改善BPSD有效率明显高于对照组（P＜0.01）。两组不良反应症状均轻微，且发生率差异无统计学意义（P＞0.05）。结论补肾化痰代表方复方海蛇胶囊联合盐酸多奈哌齐治疗BPSD的疗效优于单用盐酸多奈哌齐。
목적：평개보신화담방연합염산다내고제대중중도아이자해묵병（AD）반정신행위증상（BPSD）적료효급안전성。방법장127례AD환자안조수궤수자표법분위연구조62례화대조조65례，연구조환자복용보신화담대표방복방해사효낭화염산다내고제，대조조환자단용염산다내고제；관찰12주。치료전급치료12주말분별채용치태행위량표（BEHAVE- AD）평개정신행위증상，엄중장애량표（SIB）평정환자적인지공능。결과치료12주말，연구조BEHAVE- AD분치하강교대조조경현저（P＜0.01）；연구조치료후SIB평분여대조조적차이유통계학의의（P＜0.01）；연구조개선BPSD유효솔명현고우대조조（P＜0.01）。량조불량반응증상균경미，차발생솔차이무통계학의의（P＞0.05）。결론보신화담대표방복방해사효낭연합염산다내고제치료BPSD적료효우우단용염산다내고제。
Objective To study the efficacy and safety of Reinhartdt and sea cucumber capsule (RSC) combined with donepezil on behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's Disease. Methods One hundred and sixty seven patients were randomized into combined group and Donepezil group, and both groups were treated re-spectively for 12 weeks. The curative effect was evaluated according to SIB and BEHAVE- AD score. Results Compared with the baseline, BEHAVE- AD scores decreased significantly both in the two groups after 12 weeks of treatment (both P<0.001), but the improvement in the combined treatment group was more obvious than that in Donepezil group (P<0.01). Among the two groups, SIB score increased significantly only in the combined treatment group (P<0.001). No obvious adverse reaction occurred in the two groups. Conclusion RSC combined with Donepezil is more effective in treatment of BPSD than single Donepezil.