浙江医学
浙江醫學
절강의학
ZHEJIANG MEDICAL JOURNAL
2013年
23期
2080-2082
,共3页
围生期心肌病%超敏C反应蛋白%B型脑钠肽
圍生期心肌病%超敏C反應蛋白%B型腦鈉肽
위생기심기병%초민C반응단백%B형뇌납태
Peripartum cardiomyopathy%High sensitive C- reaction protein%B type brian natriuretic peptide
目的：探讨血清B型脑钠肽（BNP）与超敏C反应蛋白（hs- CRP）水平在围生期心肌病（PPCM）诊断及治疗中的价值。方法测定21例PPCM患者（观察组）BNP hs- CRP，同时行心脏彩色多普勒超声心动图检查测量左心室舒张末期内径（LVED）和左心室射血分数（LVEF），并对患者进行1个月的随访。选取同期住院的正常分娩患者20例作为对照组。结果观察组与对照组比较，BNP[（870.1±168.2）ng/L，（99.2±38.3）ng/L]、hs- CRP[（28.1±7.2）mg/L，（6.7±2.2）mg/L]明显升高（均P＜0.01），hs- CRP与BNP呈正相关（r＝0.67，P＜0.01）。经过1个月治疗，观察组平均LVEF由（33.1±9.5）％提高至（50.3±12.1）％，BNP、hs- CRP[治疗后分别为（196.6±40.2）ng/L、（7.8±3.1）mg/L)]明显下降（均P＜0.01）。结论 BNP及hs- CRP可以作为PPCM较好的诊断、治疗参考指标。
目的：探討血清B型腦鈉肽（BNP）與超敏C反應蛋白（hs- CRP）水平在圍生期心肌病（PPCM）診斷及治療中的價值。方法測定21例PPCM患者（觀察組）BNP hs- CRP，同時行心髒綵色多普勒超聲心動圖檢查測量左心室舒張末期內徑（LVED）和左心室射血分數（LVEF），併對患者進行1箇月的隨訪。選取同期住院的正常分娩患者20例作為對照組。結果觀察組與對照組比較，BNP[（870.1±168.2）ng/L，（99.2±38.3）ng/L]、hs- CRP[（28.1±7.2）mg/L，（6.7±2.2）mg/L]明顯升高（均P＜0.01），hs- CRP與BNP呈正相關（r＝0.67，P＜0.01）。經過1箇月治療，觀察組平均LVEF由（33.1±9.5）％提高至（50.3±12.1）％，BNP、hs- CRP[治療後分彆為（196.6±40.2）ng/L、（7.8±3.1）mg/L)]明顯下降（均P＜0.01）。結論 BNP及hs- CRP可以作為PPCM較好的診斷、治療參攷指標。
목적：탐토혈청B형뇌납태（BNP）여초민C반응단백（hs- CRP）수평재위생기심기병（PPCM）진단급치료중적개치。방법측정21례PPCM환자（관찰조）BNP hs- CRP，동시행심장채색다보륵초성심동도검사측량좌심실서장말기내경（LVED）화좌심실사혈분수（LVEF），병대환자진행1개월적수방。선취동기주원적정상분면환자20례작위대조조。결과관찰조여대조조비교，BNP[（870.1±168.2）ng/L，（99.2±38.3）ng/L]、hs- CRP[（28.1±7.2）mg/L，（6.7±2.2）mg/L]명현승고（균P＜0.01），hs- CRP여BNP정정상관（r＝0.67，P＜0.01）。경과1개월치료，관찰조평균LVEF유（33.1±9.5）％제고지（50.3±12.1）％，BNP、hs- CRP[치료후분별위（196.6±40.2）ng/L、（7.8±3.1）mg/L)]명현하강（균P＜0.01）。결론 BNP급hs- CRP가이작위PPCM교호적진단、치료삼고지표。
Objective To explore the clinical significances of the level changes of B type brain natriuretic peptide (BNP) and high sensitive C- reaction protein(hs- CRP) for diagnosis and treatment in peripartum cardiomyopathy(PPCM ). Methods A total of 21 PPCM and 20 normal delivery femals were randomly recruited in the current study.echocardiographic,hs- CRP,BNP were measured.21PPCM were fol owed up for a month. Results The PPCM patients compared to the controls, BNP(870.1ng/L) and hs- CRP (28.1mg/L) were significantly higher in the PPCM patients compared with the control (99.2ng/L and 6.7mg/L) hs- CRP was positively related with BNP(r=0.67,P<0.01).After a month of treatment,left ventricular ejection fraction enhanced from 33.1%to 50.3%, BNP significantly declined from 870.1ng/L to 196.6ng/L(P<0.01),hs- CRP significantly declined from 28.1mg/L to 7.8mg/L(P<0.01). Conclusion BNP and hs- CRP provide a good reference index for diagnosis and treatment in the PPCM.
