中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
33期
315-316
,共2页
坦洛新%托特罗定%膀胱过度活动症%输尿管支架管
坦洛新%託特囉定%膀胱過度活動癥%輸尿管支架管
탄락신%탁특라정%방광과도활동증%수뇨관지가관
Tamlosin%Tolterodine%Overactive blader symptom%Ureteral stent
目的：观察坦洛新联合托特罗定治疗留置双J管后相关症状的效果。方法输尿管镜碎石术后留置双J管患者106例，随机分为2组， A组（坦洛新组）：接受坦洛新（0.2mg 1次/d）治疗；B组（联合用药组）：接受坦洛新（0.2mg 1次/d）和托特罗定（2mg 2次/d）治疗。106例患者随访4周，术前1d及术后4周拔双J管时填写IPSS评分表、膀胱过度活动症症状评分（OABSS）及生活质量评分（QOL）量表。结果106例患者均完成研究。两组术后4周尿急症状评分分别为（3.3±0.9）分与（0.9±0.2）分；IPSS评分分别为（11.5±1.8）分与（8.9±1.3）分；OABSS评分分别为（8.3±1.8）分与（3.7±1.6）分；QOL评分分别为（39.7±13.2）分与（18.2±10.6）分，组间比较差异均有统计学意义（P＜0.05）。结论留置双J输尿管支架管严重影响患者生活质量，坦洛新联合托特罗定能明显改善留置输尿管支架管后相关症状，提高患者生活质量。
目的：觀察坦洛新聯閤託特囉定治療留置雙J管後相關癥狀的效果。方法輸尿管鏡碎石術後留置雙J管患者106例，隨機分為2組， A組（坦洛新組）：接受坦洛新（0.2mg 1次/d）治療；B組（聯閤用藥組）：接受坦洛新（0.2mg 1次/d）和託特囉定（2mg 2次/d）治療。106例患者隨訪4週，術前1d及術後4週拔雙J管時填寫IPSS評分錶、膀胱過度活動癥癥狀評分（OABSS）及生活質量評分（QOL）量錶。結果106例患者均完成研究。兩組術後4週尿急癥狀評分分彆為（3.3±0.9）分與（0.9±0.2）分；IPSS評分分彆為（11.5±1.8）分與（8.9±1.3）分；OABSS評分分彆為（8.3±1.8）分與（3.7±1.6）分；QOL評分分彆為（39.7±13.2）分與（18.2±10.6）分，組間比較差異均有統計學意義（P＜0.05）。結論留置雙J輸尿管支架管嚴重影響患者生活質量，坦洛新聯閤託特囉定能明顯改善留置輸尿管支架管後相關癥狀，提高患者生活質量。
목적：관찰탄락신연합탁특라정치료류치쌍J관후상관증상적효과。방법수뇨관경쇄석술후류치쌍J관환자106례，수궤분위2조， A조（탄락신조）：접수탄락신（0.2mg 1차/d）치료；B조（연합용약조）：접수탄락신（0.2mg 1차/d）화탁특라정（2mg 2차/d）치료。106례환자수방4주，술전1d급술후4주발쌍J관시전사IPSS평분표、방광과도활동증증상평분（OABSS）급생활질량평분（QOL）량표。결과106례환자균완성연구。량조술후4주뇨급증상평분분별위（3.3±0.9）분여（0.9±0.2）분；IPSS평분분별위（11.5±1.8）분여（8.9±1.3）분；OABSS평분분별위（8.3±1.8）분여（3.7±1.6）분；QOL평분분별위（39.7±13.2）분여（18.2±10.6）분，조간비교차이균유통계학의의（P＜0.05）。결론류치쌍J수뇨관지가관엄중영향환자생활질량，탄락신연합탁특라정능명현개선류치수뇨관지가관후상관증상，제고환자생활질량。
Objective To evaluate the effect of combination therapy with tamlosin and tolterodine improving symtoms in patients with indweling double-J ureteral stents. Methods A total of 106 patients underwent placement of a double-J ureteral stent after retrograde ureteroscopy for urinary stone disease, which were prospectively randomized (random numbers table) into two groups. The tamlosin group (n=53) was administered tamlosin 0.2 mg once daily, the combination group (n=53) was administered tamlosin 0.2 mg once daily and tolterodine 2 mg twice daily. All the patients completed a validated the Overactive Blader Symptom Score(OABSS) urgency score, the International Prostate Symtom Score (IPSS), the Overactive Blader Symptom Score(OABSS), the Quality Of Life Score (QOL) one day before the placement and 4 weeks after stent placement of stent. Results There was a statistically signiifcant difference between tamlosin group and combination group in the OABSS urgency score (3.3±0.9vs0.9±0.2), IPSS score (11.5±1.8vs8.9±1.3), OABSS score(8.3±1.8vs3.7±1.65), QOL score(39.7±13.2vs18.2±10.6)at the 4 week follow-up. Differences between groups were statistically signiifcant (P<0.05).Conclusions Indwelling ureteral stents have a signiifcant impact on health related quality of life. It is effective for improving symptoms in patients with indwelling double-J ureteral stents by combination therapy with tamlosin and tolterodine.
