中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
33期
35-36
,共2页
精神分裂症者%奥氮平%利培酮%心电图改变
精神分裂癥者%奧氮平%利培酮%心電圖改變
정신분렬증자%오담평%리배동%심전도개변
Schizophrenia%Olanzapine%Risperidone%ECG changes
目的:了解服用奥氮平、利培酮治疗精神分裂症患者心电图变化情况。方法随机对服用奥氮平160例,利培酮60例精神分裂症患者心电图进行分析。结果奥氮平组心电图表现正常65例(40.63%),心电图异常95例(59.37%)。利培酮组心电图表现正常22例(36.67%)心电图异常38例(63.33%),两药均可引起心电图改变。主要窦性心动过速,过缓,心律不齐,ST-T改变,T波异常,Q-T间期延长,短P-R间期,U波改变。二者无明显差异(P>0.05)。随着用药时间和剂量的增加两药的心电图异常率亦增加。结论奥氮平与利培酮都会影响心电图改变,特别在药物增加和大剂量长期应用患者应复查心电图。
目的:瞭解服用奧氮平、利培酮治療精神分裂癥患者心電圖變化情況。方法隨機對服用奧氮平160例,利培酮60例精神分裂癥患者心電圖進行分析。結果奧氮平組心電圖錶現正常65例(40.63%),心電圖異常95例(59.37%)。利培酮組心電圖錶現正常22例(36.67%)心電圖異常38例(63.33%),兩藥均可引起心電圖改變。主要竇性心動過速,過緩,心律不齊,ST-T改變,T波異常,Q-T間期延長,短P-R間期,U波改變。二者無明顯差異(P>0.05)。隨著用藥時間和劑量的增加兩藥的心電圖異常率亦增加。結論奧氮平與利培酮都會影響心電圖改變,特彆在藥物增加和大劑量長期應用患者應複查心電圖。
목적:료해복용오담평、리배동치료정신분렬증환자심전도변화정황。방법수궤대복용오담평160례,리배동60례정신분렬증환자심전도진행분석。결과오담평조심전도표현정상65례(40.63%),심전도이상95례(59.37%)。리배동조심전도표현정상22례(36.67%)심전도이상38례(63.33%),량약균가인기심전도개변。주요두성심동과속,과완,심률불제,ST-T개변,T파이상,Q-T간기연장,단P-R간기,U파개변。이자무명현차이(P>0.05)。수착용약시간화제량적증가량약적심전도이상솔역증가。결론오담평여리배동도회영향심전도개변,특별재약물증가화대제량장기응용환자응복사심전도。
Objective Taking olanzapine, risperidone schizophrenia ECG changes. Methods Randomly taking olanzapine 160 cases, risperidone 60 cases of schizophrenia ECG analysis. Methods randomly taking olanzapine 160 cases, risperidone 60 cases of schizophrenia ECG analysis. Results Olanzapine group electrocardiogram was normal 65 cases (40.63%), abnormal electrocardiogram 95 cases (59.37%). Risperidone group electrocardiogram was normal 22 cases (36.67%) abnormal electrocardiogram 38 cases (63.33%), two drugs can cause ECG changes. Major sinus tachycardia, bradycardia, arrhythmia, ST-T changes, T wave abnormalities, QT interval prolongation, short PR interval, U wave changes. No signiifcant difference between the two (P>0.05). With the increase in treatment time and dose rate of abnormal ECG two drugs also increased. Conclusion Olanzapine and risperidone affect electrocardiographic changes, particularly an increase in drug and long-term use of high-dose patients should review the ECG.