CAJ | 학술논문

目的：观察通心络胶囊对急性心肌梗死患者行急诊冠状动脉支架手术中发生无复流的风险及近期预后的影响。方法急性心肌梗死患者120例，随机分为服用通心络组（治疗组， n ＝48）和未服用通心络组（对照组， n ＝72），治疗组术前均连续服用通心络胶囊1周以上（2～4粒，3次/d），对照组术前均未服用通心络胶囊，按常规方法行急诊支架置入术。观察术中TIMI血流分级，术后校正心肌梗死溶栓试验血流分级帧数（ CTFC），术后心功能等。结果治疗组术中无复流5例（10．4％），对照组11例（15．3％），2组比较差异无统计学意义（ P ＞0．05）。治疗组术后CTFC为（26．7±8．3）帧，对照组为（29．7±7．2）帧，2组比较差异有统计学意义（ P ＜0．05）。术后1周治疗组LVEF为（52．7±8．0）％优于对照组（48．5±8．8）％，治疗组NT-proBNP为（1217±1363）pg/ml低于对照组的（1815±1493） pg/ml（ P均＜0．05）。结论术前服用通心络胶囊不能降低急性心肌梗死支架术中无复流的发生率，但仍可以提高冠状动脉向前血流，改善心功能。
목적：관찰통심락효낭대급성심기경사환자행급진관상동맥지가수술중발생무복류적풍험급근기예후적영향。방법급성심기경사환자120례，수궤분위복용통심락조（치료조， n ＝48）화미복용통심락조（대조조， n ＝72），치료조술전균련속복용통심락효낭1주이상（2～4립，3차/d），대조조술전균미복용통심락효낭，안상규방법행급진지가치입술。관찰술중TIMI혈류분급，술후교정심기경사용전시험혈류분급정수（ CTFC），술후심공능등。결과치료조술중무복류5례（10．4％），대조조11례（15．3％），2조비교차이무통계학의의（ P ＞0．05）。치료조술후CTFC위（26．7±8．3）정，대조조위（29．7±7．2）정，2조비교차이유통계학의의（ P ＜0．05）。술후1주치료조LVEF위（52．7±8．0）％우우대조조（48．5±8．8）％，치료조NT-proBNP위（1217±1363）pg/ml저우대조조적（1815±1493） pg/ml（ P균＜0．05）。결론술전복용통심락효낭불능강저급성심기경사지가술중무복류적발생솔，단잉가이제고관상동맥향전혈류，개선심공능。
Objective To observe the effect of Tongxinluo capsule on acute myocardial infarction underwent emer-gency coronary stent with risks of no-reflow and short-term prognosis.Methods 120 patients with acute myocardial infarction were randomly divided into taking Tongxinluo group (treatment group, n =48) and without taking Tongxinluo capsule (con-trol group, n =72), preoperative treatment group were continuously taking Tongxinluo more than 1 week (2 to 4, 3 times a day) , the control group didn't taking Tongxinluo capsule by conventional methods underwent emergency stenting .TIMI flow grade intraoperative and postoperative corrected TIMI flow grade test frames ( CTFC) , cardiac function and so on .Results Treatment group were with no-reflow in five cases (10.4%), in the control group of 11 patients (15.3%), the two groups showed no significant difference ( P >0.05).CTFC postoperative in treatment group was (26.7 ±8.3) frame, the control group was(29.7 ±7.2) frames, 2 groups'difference was statistically significant ( P <0.05).After one week, LVEF in treat-ment group was (52.7 ±8.0)%, is better than the control group with (48.5 ±8.8)%, NT-proBNP was (1217 ±1363 ) pg /ml in treatment group, lower than the control group with (1815 ±1493) pg /ml ( P <0.05).Conclusion Preoperative ta king Tongxinluo capsule cannot reduce stenting in acute myocardial infarction , the incidence of no-reflow, but still can im-prove coronary blood flow and improve cardiac function .